Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.33 |
| ▸ | AKT1 | P31749 | 4/20 | 0.33 |
| ▸ | PRKCB | P05771 | 1/20 | 0.32 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 2/20 | 0.32 |
| ▸ | JAK1 | P23458 | 2/20 | 0.32 |
| ▸ | TYK2 | P29597 | 2/20 | 0.32 |
| ▸ | JAK3 | P52333 | 2/20 | 0.32 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.32 |
| ▸ | MERTK | Q12866 | 1/20 | 0.32 |
| ▸ | PLAT | P00750 | 2/20 | 0.31 |
| ▸ | HTR2C | P28335 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.31 |
| ▸ | KHK | P50053 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1662533 | 0.99 | CCR3 (0.33) | CCR3RPS6KB1AKT1PRKCBRPS6KA1 | |
| Hydrochloric Acid SCHEMBL16457612 | 0.83 | RPS6KB1 (0.45) | RPS6KB1AKT1PRKCBRPS6KA1 | |
| SCHEMBL9927821 | 0.82 | GABRA1 (0.35) | RPS6KB1AKT1JAK2JAK1TYK2 | |
| Hydrochloric Acid SCHEMBL16457487 | 0.82 | RPS6KB1 (0.37) | RPS6KB1AKT1PRKCBRPS6KA1JAK2 | |
| Hydrochloric Acid SCHEMBL1662810 | 0.81 | MEN1 (0.38) | RPS6KB1AKT1JAK2JAK1TYK2 | |
| Hydrochloric Acid SCHEMBL16457091 | 0.81 | RPS6KA1 (0.37) | CCR3RPS6KB1AKT1PRKCBRPS6KA1 | |
| Hydrochloric Acid SCHEMBL16457694 | 0.79 | MEN1 (0.36) | RPS6KB1AKT1PRKCBRPS6KA1JAK2 | |
| SCHEMBL9894732 | 0.78 | KDM1A (0.33) | JAK2JAK1TYK2JAK3MEN1 | |
| Hydrochloric Acid SCHEMBL16457130 | 0.77 | MEN1 (0.35) | JAK2JAK1TYK2JAK3MEN1 | |
| Hydrochloric Acid SCHEMBL16457163 | 0.77 | GABRA1 (0.38) | RPS6KB1AKT1JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2491032-A1 | AKT INHIBITORS | Eli Lilly and Company (US) | 2012-08-29 | — | — | EP | disclosed |
| WO-2011050016-A1 | AKT INHIBITORS | ELI LILLY AND COMPANY (US) | 2011-04-28 | — | — | WO | disclosed |