Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 3/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 3/20 | 0.32 |
| ▸ | JAK1 | P23458 | 3/20 | 0.32 |
| ▸ | TYK2 | P29597 | 3/20 | 0.32 |
| ▸ | JAK3 | P52333 | 3/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL16457130 | 0.99 | MEN1 (0.35) | KDM1AHDAC1GABRA1GABRB2MEN1 | |
| Hydrochloric Acid SCHEMBL16457694 | 0.91 | MEN1 (0.36) | KDM1AGABRA1GABRB2MEN1KMT2A | |
| SCHEMBL9927821 | 0.87 | GABRA1 (0.35) | KDM1AGABRA1GABRB2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL1662810 | 0.85 | MEN1 (0.38) | KDM1AGABRA1GABRB2MEN1KMT2A | |
| SCHEMBL9894416 | 0.84 | RPS6KB1 (0.43) | — | |
| Hydrochloric Acid SCHEMBL16457146 | 0.83 | RPS6KB1 (0.42) | — | |
| Hydrochloric Acid SCHEMBL16457163 | 0.79 | GABRA1 (0.38) | GABRA1GABRB2MEN1KMT2AJAK2 | |
| SCHEMBL1662908 | 0.78 | CCR3 (0.34) | GABRA1GABRB2MEN1KMT2AJAK2 | |
| Hydrochloric Acid SCHEMBL1662533 | 0.77 | CCR3 (0.33) | GABRA1GABRB2MEN1KMT2AJAK2 | |
| Hydrochloric Acid SCHEMBL16457153 | 0.76 | MEN1 (0.35) | KDM1AGABRA1GABRB2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8436002-B2 | AKT inhibitors | ELI LILLY AND COMPANY (US) | 2013-05-07 | — | — | US | disclosed |
| US-20120149684-A1 | AKT INHIBITORS | ELI LILLY AND COMPANY (US) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149684-A1 | AKT INHIBITORS | AKT2, PIK3CA, AKT3 | KDM1A 1810/4885HDAC1 280/4885GABRA1 4243/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.