Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25802168 | 0.91 | GAA (0.57) | POLBNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL29999023 | 0.84 | MKNK2 (0.58) | KMT2AMAPT | |
| SCHEMBL23326866 | 0.84 | MKNK2 (0.58) | KMT2AMAPT | |
| SCHEMBL24412783 | 0.84 | RAB9A (0.70) | POLBNPC1RAB9ATP53SMN1; SMN2 | |
| SCHEMBL16620022 | 0.84 | CYP2D6 (0.56) | POLBNPC1RAB9ATP53CHRM1 | |
| SCHEMBL29716288 | 0.79 | GAA (0.52) | POLBNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL23240068 | 0.79 | GAA (0.52) | POLBNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL25802440 | 0.78 | GAA (0.57) | SMN1; SMN2MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL18099247 | 0.78 | POLB (0.62) | POLBTP53MEN1KMT2AALDH1A1 | |
| SCHEMBL16620422 | 0.77 | EPHX2 (0.54) | POLBNPC1RAB9ATP53CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015049325-A1 | THERAPEUTIC INHIBITORS OF CDK8 AND USES THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2015-04-09 | — | — | WO | disclosed |