Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.54 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25292715 | 0.90 | ABL1 (0.57) | TP53POLB | |
| SCHEMBL16620422 | 0.85 | EPHX2 (0.54) | CYP2D6MEN1CYP2C19KMT2ANPC1 | |
| SCHEMBL16629103 | 0.84 | POLB (0.55) | CYP2D6MEN1CYP2C19KMT2ANPC1 | |
| SCHEMBL27088109 | 0.81 | RET (0.64) | — | |
| SCHEMBL29581481 | 0.80 | RAB9A (0.76) | NPC1RAB9ATP53POLBSMN1; SMN2 | |
| SCHEMBL4935491 | 0.76 | KDR (0.65) | NPC1RAB9ATP53POLBSMN1; SMN2 | |
| SCHEMBL16380773 | 0.76 | IP6K1 (0.56) | NPC1RAB9ATP53POLBSMN1; SMN2 | |
| SCHEMBL25802168 | 0.74 | GAA (0.57) | NPC1RAB9APOLBSMN1; SMN2LMNA | |
| SCHEMBL23213588 | 0.74 | ABL1 (0.49) | MEN1KMT2ATP53POLBMAPT | |
| SCHEMBL25245565 | 0.74 | LMNA (0.56) | MEN1KMT2ALMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015049325-A1 | THERAPEUTIC INHIBITORS OF CDK8 AND USES THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2015-04-09 | — | — | WO | disclosed |
| US-20150045255-A1 | Endometrial Phase or Endometrial Cancer Biomarkers | WALFISH, PAUL (CA) | 2015-02-12 | — | — | US | disclosed |