Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRN | P28799 | 4/20 | 0.49 |
| ▸ | SORT1 | Q99523 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | TTK | P33981 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.30 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.30 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.30 |
| ▸ | PHGDH | O43175 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16629273 | 0.87 | BRD4 (0.35) | GRNSORT1KDM4EBRD4HTR2C | |
| SCHEMBL29664520 | 0.81 | BRD4 (0.36) | GRNSORT1KDM4EBRD4HTR2C | |
| SCHEMBL16629289 | 0.79 | BRD4 (0.31) | BRD4 | |
| SCHEMBL16629274 | 0.78 | BRD4 (0.34) | KDM4EBRD4HTR2CSLC6A4PAX8 | |
| SCHEMBL18019577 | 0.75 | BRD4 (0.35) | BRD4USP30PAX8TTKKAT6A | |
| SCHEMBL23627798 | 0.72 | BRD4 (0.46) | GRNSORT1KDM4EBRD4HTR2C | |
| SCHEMBL22445393 | 0.72 | CNR2 (0.32) | BRD4HTR2CSLC6A4 | |
| SCHEMBL16629271 | 0.72 | BRD4 (0.38) | KDM4EBRD4HTR2CSLC6A4PAX8 | |
| SCHEMBL16629255 | 0.70 | KDM4E (0.50) | GRNSORT1KDM4EBRD4CA1 | |
| SCHEMBL21872232 | 0.70 | BRD4 (0.36) | GRNSORT1KDM4EBRD4HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015050989-A2 | MACROCYCLIC COMPOUNDS FOR THE TREATMENT OF PROLIFERATIVE DISEASES | CS THERAPEUTICS INC. (US) | 2015-04-09 | — | — | WO | disclosed |