Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16619499 | 0.88 | ADRB3 (0.44) | ADRB3SLC6A4 | |
| SCHEMBL16619700 | 0.88 | ADRB3 (0.44) | ADRB3SLC6A4 | |
| SCHEMBL16619680 | 0.81 | ADRB3 (0.50) | ADRB3SLC6A4 | |
| SCHEMBL16619677 | 0.79 | ADRB3 (0.43) | ADRB3SLC6A4 | |
| SCHEMBL16618866 | 0.76 | ADRB3 (0.53) | ADRB3KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL16618864 | 0.76 | ADRB3 (0.53) | ADRB3KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL16629885 | 0.75 | LMNA (0.43) | LMNA | |
| SCHEMBL18210816 | 0.73 | IDO1 (0.37) | ADRB3KMT2AMEN1NPC1RAB9A | |
| SCHEMBL21278187 | 0.73 | ADRB3 (0.43) | ADRB3 | |
| SCHEMBL16630638 | 0.72 | PSEN1 (0.39) | KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015050798-A1 | NOVEL PYRROLIDINE DERIVED BETA 3 ADRENERGIC RECEPTOR AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2015-04-09 | — | — | WO | disclosed |