Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 15/20 | 0.39 |
| ▸ | BTK | Q06187 | 12/20 | 0.39 |
| ▸ | JAK2 | O60674 | 4/20 | 0.38 |
| ▸ | JAK1 | P23458 | 4/20 | 0.38 |
| ▸ | TYK2 | P29597 | 3/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.36 |
| ▸ | MERTK | Q12866 | 1/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | FLT4 | P35916 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL672447 | 0.76 | JAK2 (0.43) | JAK3JAK2JAK1TYK2AXL | |
| SCHEMBL1663991 | 0.73 | JAK3 (0.39) | JAK3BTKJAK2JAK1TYK2 | |
| SCHEMBL1662793 | 0.72 | PLK4 (0.46) | JAK3BTKJAK2JAK1TYK2 | |
| SCHEMBL1662994 | 0.69 | PLK4 (0.53) | JAK3BTKJAK2JAK1 | |
| SCHEMBL1662982 | 0.69 | JAK3 (0.42) | JAK3BTKJAK2JAK1TYK2 | |
| SCHEMBL1662557 | 0.68 | JAK3 (0.41) | JAK3BTKJAK2JAK1TYK2 | |
| SCHEMBL1663011 | 0.67 | TTK (0.45) | JAK3BTKJAK2HTR2AHTR2C | |
| SCHEMBL15122400 | 0.67 | STAT6 (0.52) | JAK3JAK2JAK1TYK2AXL | |
| SCHEMBL10203364 | 0.67 | STAT6 (0.44) | JAK3JAK2JAK1TYK2FGFR3 | |
| SCHEMBL1662894 | 0.66 | PLK4 (0.38) | JAK3BTKJAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2491039-A1 | HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS | Cellzome Limited (GB) | 2012-08-29 | — | — | EP | disclosed |
| WO-2011048082-A1 | HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS | CELLZOME LIMITED (GB) | 2011-04-28 | — | — | WO | disclosed |