Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11327985 | 0.76 | ALDH1A1 (0.52) | ALDH1A1USP2TSHRCA1CA2 | |
| SCHEMBL9190312 | 0.73 | ALDH1A1 (0.44) | ALDH1A1 | |
| SCHEMBL14920310 | 0.70 | ALDH1A1 (0.46) | ALDH1A1 | |
| SCHEMBL819682 | 0.70 | KDM4E (0.36) | ALDH1A1CA1 | |
| SCHEMBL5909694 | 0.68 | AGER (0.46) | CA1CA2CA9 | |
| SCHEMBL5553793 | 0.67 | ALDH1A1 (0.65) | ALDH1A1USP2TSHRCA1CA2 | |
| SCHEMBL331716 | 0.67 | — | — | |
| SCHEMBL5830076 | 0.67 | ALDH1A1 (0.65) | ALDH1A1USP2TSHRCA1CA2 | |
| SCHEMBL1822384 | 0.67 | ALDH1A1 (0.65) | ALDH1A1USP2TSHRCA1CA2 | |
| SCHEMBL575530 | 0.67 | ALDH1A1 (0.65) | ALDH1A1USP2TSHRCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424859-B1 | INHIBITORS OF PI3 KINASE AND / OR MTOR | AMGEN INC (US) | 2015-04-08 | — | — | EP | disclosed |
| EP-2424859-A1 | INHIBITORS OF PI3 KINASE AND / OR MTOR | Amgen, Inc (US) | 2012-03-07 | — | — | EP | disclosed |
| WO-2010126895-A1 | INHIBITORS OF PI3 KINASE AND / OR MTOR | AMGEN INC. (US) | 2010-11-04 | — | — | WO | disclosed |