Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.46 |
| ▸ | HBB | P68871 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ADK | P55263 | 13/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.38 |
| ▸ | GMNN | O75496 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.37 |
| ▸ | THPO | P40225 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18080176 | 0.83 | LMNA (0.57) | LMNAPMP22HBBMAPTSMN1; SMN2 | |
| SCHEMBL16631590 | 0.83 | LMNA (0.57) | LMNAPMP22HBBMAPTSMN1; SMN2 | |
| SCHEMBL16631355 | 0.81 | LMNA (0.52) | LMNAPMP22HBBTSHRMAPT | |
| SCHEMBL16631656 | 0.74 | LMNA (0.53) | LMNAPMP22HBBTSHRMAPT | |
| SCHEMBL16631878 | 0.74 | LMNA (0.53) | LMNAPMP22HBBTSHRMAPT | |
| SCHEMBL16631421 | 0.74 | LMNA (0.44) | LMNAPMP22HBBTSHRMAPT | |
| SCHEMBL16631886 | 0.73 | LMNA (0.49) | LMNAPMP22HBBTSHRMAPT | |
| SCHEMBL16631376 | 0.72 | LMNA (0.51) | LMNAPMP22HBBTSHRMAPT | |
| SCHEMBL18080179 | 0.72 | LMNA (0.49) | LMNAPMP22HBBMAPTSMN1; SMN2 | |
| SCHEMBL16631592 | 0.72 | LMNA (0.49) | LMNAPMP22HBBMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015051173-A2 | POLYNUCLEOTIDE MOLECULES AND USES THEREOF | MODERNA THERAPEUTICS, INC (US) | 2015-04-09 | — | — | WO | disclosed |