Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 5/20 | 0.53 |
| ▸ | BRAF | P15056 | 4/20 | 0.53 |
| ▸ | KRAS | P01116 | 3/20 | 0.53 |
| ▸ | ARAF | P10398 | 1/20 | 0.43 |
| ▸ | AGPAT2 | O15120 | 4/20 | 0.40 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.40 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 6/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.39 |
| ▸ | LCK | P06239 | 4/20 | 0.39 |
| ▸ | JAK3 | P52333 | 4/20 | 0.39 |
| ▸ | TEK | Q02763 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15289580 | 0.86 | RAF1 (0.50) | RAF1BRAFKRASARAFAGPAT2 | |
| SCHEMBL15289613 | 0.83 | RAF1 (0.78) | RAF1BRAFKRASARAFPOLB | |
| SCHEMBL15272412 | 0.79 | BRAF (0.55) | RAF1BRAFKRASARAFKCNQ3 | |
| SCHEMBL15289630 | 0.77 | PLA2G7 (0.44) | RAF1BRAFKRASRAB9ASMN1; SMN2 | |
| SCHEMBL15272670 | 0.75 | BRAF (0.46) | RAF1BRAFKRASARAFKCNQ3 | |
| SCHEMBL16632269 | 0.74 | RAF1 (0.72) | RAF1BRAFKRASARAFRAB9A | |
| SCHEMBL16632501 | 0.74 | RAF1 (0.61) | RAF1BRAFKRASARAFRAB9A | |
| SCHEMBL16632443 | 0.74 | RAF1 (0.55) | RAF1BRAFKRASARAFKDR | |
| SCHEMBL16632300 | 0.74 | RAF1 (0.53) | RAF1BRAFKRASARAFKDR | |
| SCHEMBL16632302 | 0.74 | RAF1 (0.45) | RAF1BRAFKRASARAFKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9187474-B2 | Raf inhibitor compounds | DECIPHERA PHARMACEUTICALS, LLC (US) | 2015-11-17 | — | — | US | disclosed |
| US-20150105367-A1 | RAF INHIBITOR COMPOUNDS | DECIPHERA PHARMACEUTICALS, LLC | 2015-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150105367-A1 | RAF INHIBITOR COMPOUNDS | BRAF, RAF1, NRAS | RAF1 2/4885BRAF 1/4885KRAS 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.