Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Levodopa. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 6/20 | 0.84 |
| ▸ | USP2 | O75604 | 3/20 | 0.84 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.84 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.84 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.84 |
| ▸ | RECQL | P46063 | 2/20 | 0.84 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.84 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.84 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.84 |
| ▸ | EGFR | P00533 | 1/20 | 0.84 |
| ▸ | LCK | P06239 | 1/20 | 0.84 |
| ▸ | FYN | P06241 | 1/20 | 0.84 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.84 |
| ▸ | HTR2A | P28223 | 1/20 | 0.84 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.84 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.60 |
| ▸ | PKM | P14618 | 2/20 | 0.59 |
| ▸ | ALPI | P09923 | 1/20 | 0.59 |
| ▸ | XIAP | P98170 | 1/20 | 0.59 |
| ▸ | KDM6B | O15054 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Levodopa SCHEMBL16632425 | 1.00 | SLC7A5 (0.84) | SLC7A5USP2PTGS1KDM4EALOX15 | |
| Levodopa SCHEMBL27698021 | 0.98 | SLC7A5 (0.82) | SLC7A5USP2PTGS1KDM4EALOX15 | |
| Levodopa SCHEMBL8579019 | 0.94 | SLC7A5 (0.79) | SLC7A5USP2PTGS1KDM4EALOX15 | |
| Levodopa SCHEMBL8579024 | 0.94 | SLC7A5 (0.79) | SLC7A5USP2PTGS1KDM4EALOX15 | |
| Levodopa SCHEMBL28214733 | 0.94 | SLC7A5 (0.90) | SLC7A5USP2PTGS1KDM4EALOX15 | |
| Levodopa SCHEMBL245057 | 0.94 | SLC7A5 (0.90) | SLC7A5USP2PTGS1KDM4EALOX15 | |
| Levodopa SCHEMBL245058 | 0.94 | SLC7A5 (0.90) | SLC7A5USP2PTGS1KDM4EALOX15 | |
| Levodopa SCHEMBL27841673 | 0.94 | SLC7A5 (0.96) | SLC7A5USP2PTGS1KDM4EALOX15 | |
| Levodopa SCHEMBL28182276 | 0.92 | SLC7A5 (0.82) | SLC7A5USP2PTGS1KDM4EALOX15 | |
| Levodopa SCHEMBL23853065 | 0.92 | SLC7A5 (0.87) | SLC7A5USP2PTGS1KDM4EALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118124224-A | High-strength high-toughness PVC profile and preparation method thereof | 宝天高科（广东）有限公司 | 2024-06-04 | — | — | CN | claimed |
| CN-108136118-A | Treatment acute myocardial infarction complicated has the heart first aid kit and drug administration device of severe heart failure | 黄铭河 | 2018-06-08 | — | — | CN | claimed |
| CN-107848954-A | Water-soluble L DOPA esters | 伯里兰有限责任公司 | 2018-03-27 | — | — | CN | claimed |
| CN-118124224-A | High-strength high-toughness PVC profile and preparation method thereof | 宝天高科（广东）有限公司 | 2024-06-04 | — | — | CN | disclosed |
| CN-116098082-A | Judge rodent's device of estrus | 斯贝福（北京）生物技术有限公司 | 2023-05-12 | — | — | CN | disclosed |
| CN-110511219-A | The dihydronaphthridine class compound and application thereof that phenyl replaces | GUANGDONG HEC PHARMACEUTICAL | 2019-11-29 | — | — | CN | disclosed |
| CN-110475546-A | Physiological activator carrier | LEMONEX INC | 2019-11-19 | — | — | CN | disclosed |
| CN-104945309-B | New nitroso compound and application thereof as nitroxyl donors | 卡尔迪奥克斯尔制药公司 | 2019-06-04 | — | — | CN | disclosed |
| CN-109310362-A | Cardiac function is assessed by the strain measurement value fast quantification from magnetic resonance imaging | 心肌解决方案股份有限公司 | 2019-02-05 | — | — | CN | disclosed |
| CN-109068651-A | Antiparasitic isoxazoline compounds, long-acting injectable formulations containing them, methods and uses thereof | 梅里亚股份有限公司 | 2018-12-21 | — | — | CN | disclosed |
| CN-104370909-B | Tricyclic compound | ABBVIE 公司 | 2018-09-11 | — | — | CN | disclosed |
| US-20150105463-A1 | Sodium Pyruvate Oral Rehydration Salt Composition for Treating Hypovolemia or Hyponatration Associated with Hypohydration | ZHOU, FANGQIANG (CN) | 2015-04-16 | — | — | US | disclosed |
| CN-104470524-A | Ghrelin receptor agonists for the treatment of achlorhydria | RAQUALIA PHARMA INC | 2015-03-25 | — | — | CN | disclosed |
| CN-104364228-A | Process for depigmenting keratin materials using novel resorcinol-based compounds | OREAL | 2015-02-18 | — | — | CN | disclosed |
| CN-103282348-A | Method for depigmenting keratin materials using resorcinol derivatives | OREAL | 2013-09-04 | — | — | CN | disclosed |
| CN-103228630-A | Process for depigmenting keratin materials using thiopyridone compounds | OREAL | 2013-07-31 | — | — | CN | disclosed |
| CN-101494978-A | Methods of treating stroke | BIOGEN IDEC INC (US) | 2009-07-29 | — | — | CN | disclosed |
| CN-1258221-A | Biodegradable compositions comprising poly (cycloaliphatic phosphoester_ compounds, articles, and methods for using same | GUILFORD PHARM INC (US) | 2000-06-28 | — | — | CN | disclosed |
| CN-1044652-A | Pyrrolidine compound and its pharmaceutical use | EISAI CO LTD (JP) | 1990-08-15 | — | — | CN | disclosed |
| CN-88100990-A | Improving one's methods of dobutamine salt | — | 1988-09-07 | — | — | CN | disclosed |