Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Levodopa. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 6/20 | 0.90 |
| ▸ | USP2 | O75604 | 3/20 | 0.90 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.90 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.90 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.90 |
| ▸ | RECQL | P46063 | 2/20 | 0.90 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.90 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.90 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.90 |
| ▸ | EGFR | P00533 | 1/20 | 0.90 |
| ▸ | LCK | P06239 | 1/20 | 0.90 |
| ▸ | FYN | P06241 | 1/20 | 0.90 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.90 |
| ▸ | HTR2A | P28223 | 1/20 | 0.90 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.90 |
| ▸ | PKM | P14618 | 3/20 | 0.62 |
| ▸ | ALPI | P09923 | 1/20 | 0.62 |
| ▸ | XIAP | P98170 | 1/20 | 0.62 |
| ▸ | KDM6B | O15054 | 1/20 | 0.60 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Levodopa SCHEMBL245057 | 1.00 | SLC7A5 (0.90) | SLC7A5USP2PTGS1KDM4EALOX15 | |
| Levodopa SCHEMBL245058 | 1.00 | SLC7A5 (0.90) | SLC7A5USP2PTGS1KDM4EALOX15 | |
| Levodopa SCHEMBL27841673 | 0.97 | SLC7A5 (0.96) | SLC7A5USP2PTGS1KDM4EALOX15 | |
| Levodopa SCHEMBL27642065 | 0.95 | SLC7A5 (0.87) | SLC7A5USP2PTGS1KDM4EALOX15 | |
| Levodopa SCHEMBL896629 | 0.95 | SLC7A5 (0.87) | SLC7A5USP2PTGS1KDM4EALOX15 | |
| Levodopa SCHEMBL22655 | 0.95 | SLC7A5 (1.00) | SLC7A5USP2PTGS1KDM4EALOX15 | |
| Levodopa SCHEMBL704089 | 0.95 | SLC7A5 (1.00) | SLC7A5USP2PTGS1KDM4EALOX15 | |
| Levodopa SCHEMBL29974762 | 0.95 | SLC7A5 (1.00) | SLC7A5USP2PTGS1KDM4EALOX15 | |
| Levodopa SCHEMBL20582239 | 0.95 | SLC7A5 (1.00) | SLC7A5USP2PTGS1KDM4EALOX15 | |
| Levodopa SCHEMBL29975814 | 0.95 | SLC7A5 (1.00) | SLC7A5USP2PTGS1KDM4EALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107966560-A | A kind of preparation method of the immunosensor based on chitosan-gold hybrid particle | 江南大学 | 2018-04-27 | — | — | CN | claimed |
| CN-107966560-A | A kind of preparation method of the immunosensor based on chitosan-gold hybrid particle | 江南大学 | 2018-04-27 | — | — | CN | disclosed |