Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Levodopa. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 6/20 | 0.90 |
| ▸ | USP2 | O75604 | 3/20 | 0.90 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.90 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.90 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.90 |
| ▸ | RECQL | P46063 | 2/20 | 0.90 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.90 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.90 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.90 |
| ▸ | EGFR | P00533 | 1/20 | 0.90 |
| ▸ | LCK | P06239 | 1/20 | 0.90 |
| ▸ | FYN | P06241 | 1/20 | 0.90 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.90 |
| ▸ | HTR2A | P28223 | 1/20 | 0.90 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.90 |
| ▸ | PKM | P14618 | 3/20 | 0.62 |
| ▸ | ALPI | P09923 | 1/20 | 0.62 |
| ▸ | XIAP | P98170 | 1/20 | 0.62 |
| ▸ | KDM6B | O15054 | 1/20 | 0.60 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Levodopa SCHEMBL245057 | 1.00 | SLC7A5 (0.90) | SLC7A5USP2PTGS1KDM4EALOX15 | |
| Levodopa SCHEMBL28214733 | 1.00 | SLC7A5 (0.90) | SLC7A5USP2PTGS1KDM4EALOX15 | |
| Levodopa SCHEMBL27841673 | 0.97 | SLC7A5 (0.96) | SLC7A5USP2PTGS1KDM4EALOX15 | |
| Levodopa SCHEMBL27642065 | 0.95 | SLC7A5 (0.87) | SLC7A5USP2PTGS1KDM4EALOX15 | |
| Levodopa SCHEMBL896629 | 0.95 | SLC7A5 (0.87) | SLC7A5USP2PTGS1KDM4EALOX15 | |
| Levodopa SCHEMBL22655 | 0.95 | SLC7A5 (1.00) | SLC7A5USP2PTGS1KDM4EALOX15 | |
| Levodopa SCHEMBL704089 | 0.95 | SLC7A5 (1.00) | SLC7A5USP2PTGS1KDM4EALOX15 | |
| Levodopa SCHEMBL29974762 | 0.95 | SLC7A5 (1.00) | SLC7A5USP2PTGS1KDM4EALOX15 | |
| Levodopa SCHEMBL20582239 | 0.95 | SLC7A5 (1.00) | SLC7A5USP2PTGS1KDM4EALOX15 | |
| Levodopa SCHEMBL29975814 | 0.95 | SLC7A5 (1.00) | SLC7A5USP2PTGS1KDM4EALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 78 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240124656-A1 | CONDUCTIVE HYDROGEL COMPRISING MUSSEL ADHESIVE PROTEIN AND PREPARATION METHOD THEREOF | POSTECH Research and Business Development Foundation (KR) | 2024-04-18 | — | — | US | disclosed |
| US-20240090840-A1 | TRANSIENT BIO-ADHESIVE DEVICE FOR ORGAN MONITORING | POSTECH Research and Business Development Foundation (KR) | 2024-03-21 | — | — | US | disclosed |
| US-11046873-B2 | Methods of adhering in an aqueous environment | PURDUE RESEARCH FOUNDATION (US) | 2021-06-29 | — | — | US | disclosed |
| EP-3294358-B1 | DRUG COATED MEDICAL DEVICES | BOSTON SCIENT SCIMED INC (US) | 2020-04-15 | — | — | EP | disclosed |
| US-10517987-B2 | Adhesive complex coacervates and methods of making and using thereof | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2019-12-31 | — | — | US | disclosed |
| US-20190322910-A1 | METHODS OF ADHERING IN AN AQUEOUS ENVIRONMENT | PURDUE RESEARCH FOUNDATION (US) | 2019-10-24 | — | — | US | disclosed |
| CN-110294789-A | The synthetic method of the oligopeptides containing DOPA and its application in terms of anti-Parkinson's disease prodrug | 海南大学 | 2019-10-01 | — | — | CN | disclosed |
| EP-3500602-A2 | METHODS OF ADHERING IN AN AQUEOUS ENVIRONMENT | Purdue Research Foundation (US) | 2019-06-26 | — | — | EP | disclosed |
| CN-109824801-A | A kind of synthetic method of cyclodextrin modified DOPA amine derivative | 江南大学 | 2019-05-31 | — | — | CN | disclosed |
| EP-2456466-B1 | ADHESIVE COMPLEX COACERVATES AND METHODS OF MAKING AND USING THEREOF | UNIV UTAH RES FOUND (US) | 2019-05-08 | — | — | EP | disclosed |
| US-20050288398-A1 | Polymeric compositions and related methods of use | NIH - DEITR | 2005-12-29 | — | — | US | disclosed |
| WO-2005118831-A2 | POLYMERIC COMPOSITIONS AND RELATED METHODS OF USE | NORTHWESTERN UNIVERSITY (US) | 2005-12-15 | — | — | WO | disclosed |
| WO-2005056708-A3 | BIOADHESIVE POLYMERS WITH CATECHOL FUNCTIONALITY | SPHERICS INC (US) | 2005-07-28 | — | — | WO | disclosed |
| WO-2005056708-A2 | BIOADHESIVE POLYMERS WITH CATECHOL FUNCTIONALITY | SPHERICS, INC. (US) | 2005-06-23 | — | — | WO | disclosed |
| US-20030087338-A1 | Adhesive DOPA-containing polymers and related methods of use | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2003-05-08 | — | — | US | disclosed |
| WO-2003008376-A2 | ADHESIVE DOPA-CONTAINING POLYMERS AND RELATED METHODS OF USE | NORTHWESTERN UNIVERSITY (US) | 2003-01-30 | — | — | WO | disclosed |
| US-5310469-A | Apparatus for quantitative analysis, dielectric housings, conductors for currents, membranes, substrates and molecules with active material attached | ABBOTT LABORATORIES (US) | 1994-05-10 | — | — | US | disclosed |
| EP-0309827-B1 | L-DOPA DERIVATIVES OR THEIR ACID ADDITION SALTS, PROCESS FOR PRODUCING SAME AND THEIR USE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1992-01-02 | — | — | EP | disclosed |
| US-4966915-A | L-dopa derivatives or their acid addition salts, process for producing same and their use | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1990-10-30 | — | — | US | disclosed |
| EP-0309827-A1 | L-Dopa derivatives or their acid addition salts, process for producing same and their use | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1989-04-05 | — | — | EP | disclosed |