Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.33 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.33 |
| ▸ | LIPE | Q05469 | 7/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | F11 | P03951 | 1/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.32 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.32 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.32 |
| ▸ | LPL | P06858 | 1/20 | 0.31 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15271999 | 0.90 | CA1 (0.36) | CA1CA2CA9PDGFRBKDR | |
| SCHEMBL30935374 | 0.83 | FGFR1 (0.35) | CA1CA2CA9PDGFRBKDR | |
| SCHEMBL6433543 | 0.82 | EGFR (0.35) | HIF1ASMN1; SMN2 | |
| SCHEMBL15289558 | 0.80 | PDGFRB (0.33) | CA1CA2CA9PDGFRBKDR | |
| SCHEMBL18113011 | 0.80 | LIPE (0.35) | CA1CA2CA9PDGFRBKDR | |
| SCHEMBL16667637 | 0.79 | NPC1 (0.40) | CA1CA2CA9PDGFRBKDR | |
| SCHEMBL15273156 | 0.78 | HIF1A (0.47) | CA1CA2CA9PDGFRBKDR | |
| SCHEMBL2635766 | 0.78 | CA1 (0.51) | CA1CA2CA9PDGFRBKDR | |
| SCHEMBL17770661 | 0.78 | CXCR2 (0.34) | CA1CA2CA9PDGFRBKDR | |
| SCHEMBL3726907 | 0.78 | CXCR2 (0.41) | CA1CA2CA9PDGFRBKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9334267-B2 | RAF inhibitor compounds | DECIPHERA PHARMACEUTICALS, LLC (US) | 2016-05-10 | — | — | US | disclosed |
| US-9187474-B2 | Raf inhibitor compounds | DECIPHERA PHARMACEUTICALS, LLC (US) | 2015-11-17 | — | — | US | disclosed |
| US-20150119392-A1 | RAF INHIBITOR COMPOUNDS | DECIPHERA PHARMACEUTICALS, LLC | 2015-04-30 | — | — | US | disclosed |
| US-20150105367-A1 | RAF INHIBITOR COMPOUNDS | DECIPHERA PHARMACEUTICALS, LLC | 2015-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150105367-A1 | RAF INHIBITOR COMPOUNDS | BRAF, RAF1, NRAS | CA1 3961/4885CA2 1698/4885CA9 1045/4885 |
| US-20150119392-A1 | RAF INHIBITOR COMPOUNDS | BRAF, RAF1, NRAS | CA1 4150/4885CA2 2183/4885CA9 1661/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.