Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 5/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.46 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CBR1 | P16152 | 1/20 | 0.46 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.46 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | RHEB | Q15382 | 2/20 | 0.35 |
| ▸ | AHR | P35869 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16632742 | 0.86 | CYP2A6 (0.38) | SLC6A3MAPTSLC6A2CYP2A6 | |
| SCHEMBL16632479 | 0.85 | CYP2A6 (0.45) | MAPTHPGDCYP2A6MEN1KMT2A | |
| SCHEMBL16632723 | 0.84 | SLC6A4 (0.49) | TTRSLC6A3MAPTSLC6A2LMNA | |
| SCHEMBL16632654 | 0.81 | TTR (0.49) | TTRSLC6A3MAPTSLC6A2NR1I2 | |
| SCHEMBL16632567 | 0.79 | CYP2A6 (0.38) | TTRSLC6A3MAPTSLC6A2NR1I2 | |
| SCHEMBL3484201 | 0.78 | AR (0.39) | SLC6A3MAPTSLC6A2HPGDCYP2A6 | |
| SCHEMBL16632437 | 0.75 | TTR (0.51) | TTRSLC6A3MAPTSLC6A2NR1I2 | |
| SCHEMBL16632984 | 0.75 | CYP2A6 (0.45) | MAPTLMNAHPGDCYP2A6MEN1 | |
| SCHEMBL16632470 | 0.73 | TTR (0.47) | TTRSLC6A3MAPTSLC6A2NR1I2 | |
| SCHEMBL29574172 | 0.73 | TTR (0.56) | TTRSLC6A3MAPTSLC6A2NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9382245-B2 | Compounds and methods for treating HIV infections | YALE UNIVERSITY (US) | 2016-07-05 | — | — | US | disclosed |
| US-20150105351-A1 | COMPOUNDS AND METHODS FOR TREATING HIV INFECTIONS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150105351-A1 | COMPOUNDS AND METHODS FOR TREATING HIV INFECTIONS | POLM, POLRMT, DHFR | TTR 4120/4885SLC6A3 3639/4885MAPT 1046/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.