Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 6/20 | 0.40 |
| ▸ | AR | P10275 | 3/20 | 0.35 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.32 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.32 |
| ▸ | P4HB | P07237 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16632694 | 0.89 | GRM5 (0.37) | GRM5ARSCN8ASCN10AP4HB | |
| SCHEMBL16632649 | 0.86 | GRM5 (0.41) | GRM5AR | |
| SCHEMBL16632736 | 0.86 | GRM5 (0.35) | GRM5ARP4HBSLC6A2SLC6A3 | |
| SCHEMBL16632389 | 0.86 | AR (0.45) | GRM5ARSCN8ASCN10A | |
| SCHEMBL16632571 | 0.83 | GRM5 (0.37) | GRM5ARP4HB | |
| SCHEMBL16632575 | 0.79 | AR (0.39) | GRM5AR | |
| SCHEMBL16632640 | 0.78 | AR (0.49) | GRM5ARSLC6A2SLC6A3 | |
| SCHEMBL16632599 | 0.77 | AR (0.45) | GRM5ARSCN8ASCN10A | |
| SCHEMBL16632593 | 0.75 | GRM5 (0.33) | GRM5 | |
| SCHEMBL16632281 | 0.74 | TTR (0.47) | GRM5ARSLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9382245-B2 | Compounds and methods for treating HIV infections | YALE UNIVERSITY (US) | 2016-07-05 | — | — | US | disclosed |
| US-20150105351-A1 | COMPOUNDS AND METHODS FOR TREATING HIV INFECTIONS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150105351-A1 | COMPOUNDS AND METHODS FOR TREATING HIV INFECTIONS | POLM, POLRMT, DHFR | GRM5 2115/4885AR 3070/4885SCN8A 4760/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.