Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | GALR3 | O60755 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13199182 | 0.83 | CA1 (0.55) | ALDH1A1GPR35TDP1TSHRCYP3A4 | |
| SCHEMBL29314171 | 0.83 | KMT2A (0.44) | ALDH1A1GPR35TDP1TSHRMAPK1 | |
| SCHEMBL8099774 | 0.82 | ALDH1A1 (0.52) | ALDH1A1GPR35TDP1TSHRCYP3A4 | |
| SCHEMBL8094473 | 0.82 | ALDH1A1 (0.52) | ALDH1A1GPR35TDP1TSHRCYP3A4 | |
| SCHEMBL14892423 | 0.80 | ALDH1A1 (0.50) | ALDH1A1GPR35TDP1TSHRCYP3A4 | |
| SCHEMBL11505031 | 0.79 | KMT2A (0.65) | ALDH1A1GPR35TDP1TSHRMAPK1 | |
| SCHEMBL27484194 | 0.79 | MEN1 (0.50) | ALDH1A1GPR35TDP1TSHRCYP3A4 | |
| SCHEMBL31509456 | 0.78 | MAPK1 (0.47) | ALDH1A1GPR35TDP1TSHRMAPK1 | |
| SCHEMBL16633153 | 0.77 | GSK3B (0.51) | ALDH1A1GPR35TDP1TSHRMAPK1 | |
| SCHEMBL7591814 | 0.77 | ALDH1A1 (0.49) | ALDH1A1GPR35TDP1TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834695-B2 | High efficiency rheology modifers with cationic components and use thereof | HERCULES LLC (US) | 2017-12-05 | — | — | US | claimed |
| US-20150105500-A1 | HIGH EFFICIENCY RHEOLOGY MODIFERS WITH CATIONIC COMPONENTS AND USE THEREOF | AVOCA LLC | 2015-04-16 | — | — | US | claimed |
| US-9834695-B2 | High efficiency rheology modifers with cationic components and use thereof | HERCULES LLC (US) | 2017-12-05 | — | — | US | disclosed |
| US-9670197-B2 | Small molecule modifiers of the Hec1-Nek2 interaction in G2/M | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-06-06 | — | — | US | disclosed |
| US-20160318918-A1 | SMALL MOLECULE MODIFIERS OF THE HEC1-NEK2 INTERACTION IN G2/M | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-11-03 | — | — | US | disclosed |
| US-9422275-B2 | Small molecule modifiers of the HEC1-NEK2 interaction in G2/M | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-08-23 | — | — | US | disclosed |
| US-20150105500-A1 | HIGH EFFICIENCY RHEOLOGY MODIFERS WITH CATIONIC COMPONENTS AND USE THEREOF | AVOCA LLC | 2015-04-16 | — | — | US | disclosed |
| US-20150105391-A1 | SMALL MOLECULE MODIFIERS OF THE HEC1-NEK2 INTERACTION IN G2/M | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2015-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160318918-A1 | SMALL MOLECULE MODIFIERS OF THE HEC1-NEK2 INTERACTION IN G2/M | NR2E1, NEK4, NCOR2 | ALDH1A1 3515/4885GPR35 2682/4885TDP1 3355/4885 |
| US-20150105391-A1 | SMALL MOLECULE MODIFIERS OF THE HEC1-NEK2 INTERACTION IN G2/M | NR2E1, NEK4, NCOR2 | ALDH1A1 3515/4885GPR35 2682/4885TDP1 3355/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.