Deoxyuridine — predicted protein targets

Known targets — ChEMBL curated mechanism

ADRA1A ADRA1B ADRA1D ADRB1 ADRB2 ADRB3 CYP11B1 DPP4 FGFR1 FGFR2 FGFR3 FGFR4 HRH1 JAK1 JAK2 JAK3 KCNA1 KCNA10 KCNA2 KCNA3 KCNA4 KCNA5 KCNA6 KCNA7 KCNB1 KCNB2 KCNC1 KCNC2 KCNC3 KCNC4 KCND1 KCND2 KCND3 KCNF1 KCNG1 KCNG2 KCNG3 KCNG4 KCNH1 KCNH2 KCNH3 KCNH4 KCNH5 KCNH6 KCNH7 KCNH8 KCNQ1 KCNQ2 KCNQ3 KCNQ4 KCNQ5 KCNS1 KCNS2 KCNS3 KCNV1 KCNV2 KDR KIT NA OPRD1 OPRK1 OPRM1 P PDGFRB PIK3CD SCN10A SCN11A SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A SCN9A SMO TYK2 pol rplA rplB rplC rplD rplE rplF rplJ rplK rplL rplM rplN rplO rplP rplQ rplR rplS rplT rplU rplV rplW rplX rplY rpmA rpmB rpmC rpmD rpmE rpmF rpmG rpmH rpmI rpmJ rpsA rpsB rpsC rpsD rpsE rpsF rpsG rpsH rpsI rpsJ rpsK rpsL rpsM rpsN rpsO rpsP rpsQ rpsR rpsS rpsT rpsU ykgM ykgO

The experimentally established mechanism targets of Deoxyuridine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 15)

	gene	UniProt	supporting neighbours	confidence
▸	ADRA1A known ✓	P35348	1/20	0.50

▸	DUT	P33316	4/20	0.68

▸	P2RY2	P41231	4/20	0.53

▸	P2RY6	Q15077	3/20	0.53

▸	LMNA	P02545	2/20	0.53

▸	SMN1; SMN2	Q16637	2/20	0.53

▸	TK1	P04183	2/20	0.53

▸	SLC28A1	O00337	1/20	0.51

▸	SLC28A2	O43868	1/20	0.51

▸	SLC29A1	Q99808	1/20	0.51

▸	SLC28A3	Q9HAS3	1/20	0.51

▸	P2RY4	P51582	2/20	0.51

▸	ALOX12	P18054	1/20	0.50

▸	TK2	O00142	1/20	0.49

▸	TYMS	P04818	1/20	0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Deoxyuridine SCHEMBL156693	0.99	DUT (0.70)	DUTP2RY2P2RY6LMNASMN1; SMN2
Deoxyuridine SCHEMBL1501332	0.95	DUT (0.64)	DUTLMNASMN1; SMN2TK1SLC28A1
Deoxyuridine SCHEMBL157130	0.95	DUT (0.64)	DUTLMNASMN1; SMN2TK1SLC28A1
Deoxyuridine SCHEMBL20585969	0.95	DUT (0.64)	DUTLMNASMN1; SMN2TK1SLC28A1
Deoxyuridine SCHEMBL27615744	0.95	DUT (0.64)	DUTLMNASMN1; SMN2TK1SLC28A1
Deoxyuridine SCHEMBL3709892	0.95	DUT (0.64)	DUTLMNASMN1; SMN2TK1SLC28A1
Deoxyuridine SCHEMBL15199	0.95	DUT (0.64)	DUTLMNASMN1; SMN2TK1SLC28A1
Deoxyuridine SCHEMBL6066345	0.94	DUT (0.67)	DUTP2RY2P2RY6LMNASMN1; SMN2
Deoxyuridine SCHEMBL3961108	0.94	DUT (0.63)	DUTLMNASMN1; SMN2TK1SLC28A1
Deoxyuridine SCHEMBL20585970	0.94	DUT (0.66)	DUTP2RY2P2RY6P2RY4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2016168735-A1	NUCLEOSIDE SUPPLEMENTATION TO PROMOTE CELLULAR FUNCTION, GENETIC STABILITY AND AUGMENT TRANSGENIC EXPRESSION	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US)	2016-10-20	—	—	WO	disclosed
EP-3058061-A1	NUCLEOSIDE SUPPLEMENTATION TO PROMOTE CELLULAR FUNCTION, GENETIC STABILITY AND REGENERATIVE APPLICATIONS	The Regents of the University of California (US)	2016-08-24	—	—	EP	disclosed
WO-2015057997-A1	NUCLEOSIDE SUPPLEMENTATION TO PROMOTE CELLULAR FUNCTION, GENETIC STABILITY AND REGENERATIVE APPLICATIONS	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US)	2015-04-23	—	—	WO	disclosed
US-20150105343-A1	NUCLEOSIDE SUPPLEMENTATION TO PROMOTE CELLULAR FUNCTION, GENETIC STABILITY AND REGENERATIVE APPLICATIONS	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA	2015-04-16	—	—	US	disclosed