Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | NMBR | P28336 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | MME | P08473 | 3/20 | 0.54 |
| ▸ | ECE1 | P42892 | 3/20 | 0.54 |
| ▸ | TACR1 | P25103 | 2/20 | 0.53 |
| ▸ | PLG | P00747 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.51 |
| ▸ | PPARG | P37231 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | ACE | P12821 | 1/20 | 0.51 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17938398 | 0.94 | MAPT (0.62) | MAPTLMNANMBRGAAHTT | |
| SCHEMBL16645287 | 0.94 | MAPT (0.62) | MAPTLMNANMBRGAAHTT | |
| SCHEMBL17938396 | 0.93 | MAPT (0.60) | MAPTLMNANMBRGAAHTT | |
| SCHEMBL7433854 | 0.88 | KMT2A (0.66) | MAPTLMNANMBRGAAHTT | |
| SCHEMBL19068574 | 0.87 | MAPT (0.60) | MAPTLMNANMBRGAAHTT | |
| SCHEMBL16645286 | 0.87 | MAPT (0.60) | MAPTLMNANMBRGAAHTT | |
| SCHEMBL10899582 | 0.85 | NMBR (0.62) | MAPTLMNANMBRGAAHTT | |
| SCHEMBL7436159 | 0.85 | NMBR (0.62) | MAPTLMNANMBRGAAHTT | |
| SCHEMBL3036857 | 0.85 | NMBR (0.62) | MAPTLMNANMBRGAAHTT | |
| SCHEMBL3808330 | 0.85 | NMBR (0.76) | MAPTLMNANMBRGAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3054951-A1 | INHIBITOR OF BREAST CANCER RESISTANCE PROTEIN (BCRP) | Millennium Pharmaceuticals, Inc. (US) | 2016-08-17 | — | — | EP | disclosed |
| WO-2015054132-A1 | INHIBITOR OF BREAST CANCER RESISTANCE PROTEIN (BCRP) | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2015-04-16 | — | — | WO | disclosed |