Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NMBR | P28336 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | MME | P08473 | 3/20 | 0.57 |
| ▸ | ECE1 | P42892 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | PLG | P00747 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | HTR1A | P08908 | 1/20 | 0.55 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | HTR2A | P28223 | 1/20 | 0.55 |
| ▸ | HTR2C | P28335 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10899582 | 1.00 | NMBR (0.62) | NMBRKMT2AMEN1MAPTGAA | |
| SCHEMBL3036857 | 1.00 | NMBR (0.62) | NMBRKMT2AMEN1MAPTGAA | |
| SCHEMBL3072927 | 0.96 | NMBR (0.63) | NMBRKMT2AMEN1MAPTGAA | |
| SCHEMBL27738734 | 0.96 | NMBR (0.63) | NMBRKMT2AMEN1MAPTGAA | |
| SCHEMBL10972700 | 0.94 | NMBR (0.61) | NMBRKMT2AMEN1MAPTGAA | |
| SCHEMBL10968279 | 0.93 | NMBR (0.68) | NMBRMAPTGAAHTTMME | |
| SCHEMBL3065558 | 0.92 | PLG (0.63) | NMBRKMT2AMEN1MAPTGAA | |
| SCHEMBL4941526 | 0.91 | NMBR (0.59) | NMBRKMT2AMEN1MAPTGAA | |
| SCHEMBL10968949 | 0.90 | NMBR (0.58) | NMBRKMT2AMEN1MAPTGAA | |
| SCHEMBL8197468 | 0.90 | TGM2 (0.65) | NMBRKMT2AMEN1MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0916671-B1 | Metalloprotease inhibitors, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2002-01-30 | — | — | EP | disclosed |
| US-6066633-A | PREVENT TISSUE DEGRADATION | ADIR ET COMPAGNIE (FR) | 2000-05-23 | — | — | US | disclosed |
| CN-1217332-A | Metal protease inhibitor, preparation method therefor and medicinal composition containing same | ADIR (FR) | 1999-05-26 | — | — | CN | disclosed |
| EP-0916671-A1 | Metalloprotease inhibitors, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1999-05-19 | — | — | EP | disclosed |