Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.66 |
| ▸ | MEN1 | O00255 | 3/20 | 0.66 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.62 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.62 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 4/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.58 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.58 |
| ▸ | ITGAL | P20701 | 1/20 | 0.58 |
| ▸ | TACR1 | P25103 | 2/20 | 0.58 |
| ▸ | NMBR | P28336 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.56 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.56 |
| ▸ | LTA4H | P09960 | 1/20 | 0.56 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.56 |
| ▸ | MME | P08473 | 2/20 | 0.54 |
| ▸ | ECE1 | P42892 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10899901 | 0.89 | KMT2A (0.65) | KMT2AMEN1SIRT2SIRT1SIRT3 | |
| SCHEMBL10968952 | 0.89 | KMT2A (0.65) | KMT2AMEN1SIRT2SIRT1SIRT3 | |
| SCHEMBL11866933 | 0.89 | KMT2A (0.74) | KMT2AMAPTLMNAITGB2ICAM1 | |
| SCHEMBL16634516 | 0.88 | MAPT (0.62) | KMT2AMEN1MAPTLMNATACR1 | |
| SCHEMBL7436159 | 0.88 | NMBR (0.62) | KMT2AMEN1MAPTLMNANMBR | |
| SCHEMBL3036857 | 0.88 | NMBR (0.62) | KMT2AMEN1MAPTLMNANMBR | |
| SCHEMBL10899582 | 0.88 | NMBR (0.62) | KMT2AMEN1MAPTLMNANMBR | |
| SCHEMBL16645245 | 0.86 | MAPT (0.61) | KMT2AMEN1SIRT2SIRT1SIRT3 | |
| SCHEMBL17938406 | 0.86 | MAPT (0.61) | KMT2AMEN1SIRT2SIRT1SIRT3 | |
| SCHEMBL8197468 | 0.86 | TGM2 (0.65) | KMT2AMEN1MAPTLMNAITGB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0916671-B1 | Metalloprotease inhibitors, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2002-01-30 | — | — | EP | disclosed |
| US-6066633-A | PREVENT TISSUE DEGRADATION | ADIR ET COMPAGNIE (FR) | 2000-05-23 | — | — | US | disclosed |
| EP-0916671-A1 | Metalloprotease inhibitors, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1999-05-19 | — | — | EP | disclosed |