Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.69 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.62 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.62 |
| ▸ | HCAR3 | P49019 | 4/20 | 0.60 |
| ▸ | MAPT | P10636 | 5/20 | 0.59 |
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MYC | P01106 | 1/20 | 0.50 |
| ▸ | MAX | P61244 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.47 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.47 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16634553 | 1.00 | KMT2A (0.69) | KMT2AAKR1C3AKR1C2HCAR3MAPT | |
| SCHEMBL16634609 | 0.85 | KMT2A (0.71) | KMT2AAKR1C3AKR1C2HCAR3MAPT | |
| SCHEMBL16634606 | 0.85 | KMT2A (0.71) | KMT2AAKR1C3AKR1C2HCAR3MAPT | |
| SCHEMBL16634591 | 0.80 | GAA (0.59) | KMT2AAKR1C3AKR1C2MAPTMEN1 | |
| SCHEMBL26931842 | 0.77 | KMT2A (0.80) | KMT2AAKR1C3AKR1C2HCAR3MAPT | |
| SCHEMBL16634689 | 0.76 | HCAR3 (0.67) | KMT2AAKR1C3AKR1C2HCAR3MAPT | |
| SCHEMBL16634690 | 0.76 | HCAR3 (0.67) | KMT2AAKR1C3AKR1C2HCAR3MAPT | |
| SCHEMBL10531646 | 0.75 | TDP1 (0.61) | KMT2AAKR1C3AKR1C2HCAR3MAPT | |
| SCHEMBL2338616 | 0.75 | HCAR3 (1.00) | KMT2AAKR1C3AKR1C2HCAR3MAPT | |
| SCHEMBL589368 | 0.75 | RXRA (0.50) | HCAR3HTTSMN1; SMN2HPGDTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015052675-A1 | SUBSTITUTED DIHYDRO-BENZIMIDAZOLE COMPOUNDS AS ROR GAMMA MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2015-04-16 | — | — | WO | disclosed |