Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 18/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.56 |
| ▸ | PPARG | P37231 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16634554 | 0.89 | RORC (0.55) | RORCCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL16634596 | 0.85 | RORC (0.61) | RORCCYP3A4CYP2C9PPARGCYP2C19 | |
| SCHEMBL16634653 | 0.84 | RORC (0.60) | RORCCYP3A4CYP2C9PPARGCYP2C19 | |
| SCHEMBL16634706 | 0.81 | RORC (0.48) | RORCCYP3A4CYP2C9PPARGCYP2C19 | |
| SCHEMBL16634830 | 0.78 | RORC (0.43) | RORCCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL16634779 | 0.78 | RORC (0.53) | RORCCYP3A4CYP2C9PPARGCYP2C19 | |
| SCHEMBL16634652 | 0.77 | RORC (0.50) | RORCCYP3A4CYP2C9PPARGCYP2C19 | |
| SCHEMBL16634775 | 0.77 | RORC (0.63) | RORCCYP3A4CYP2C9PPARGCYP2C19 | |
| SCHEMBL16634618 | 0.76 | RORC (0.45) | RORCCYP3A4CYP2C9PPARGCYP2C19 | |
| SCHEMBL16634647 | 0.76 | RORC (0.54) | RORCCYP3A4CYP2C9PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015052675-A1 | SUBSTITUTED DIHYDRO-BENZIMIDAZOLE COMPOUNDS AS ROR GAMMA MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2015-04-16 | — | — | WO | disclosed |