Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 8/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.59 |
| ▸ | MAPT | P10636 | 5/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.59 |
| ▸ | THRB | P10828 | 3/20 | 0.59 |
| ▸ | HPGD | P15428 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | GFER | P55789 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.51 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.51 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27498159 | 0.88 | MAPK13 (0.64) | GAAKDM4EMAPTALDH1A1HSD17B10 | |
| SCHEMBL16634723 | 0.79 | MAP2K1 (0.54) | GAAKDM4EMAPTALDH1A1HSD17B10 | |
| SCHEMBL16634860 | 0.77 | HCAR3 (0.63) | GAAMAPTALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL16634858 | 0.77 | HCAR3 (0.63) | GAAMAPTALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL29581577 | 0.77 | ALDH1A1 (0.47) | GAAKDM4EMAPTALDH1A1HSD17B10 | |
| SCHEMBL3606443 | 0.77 | ALDH1A1 (0.47) | GAAKDM4EMAPTALDH1A1HSD17B10 | |
| SCHEMBL18640986 | 0.77 | GAA (0.69) | GAAKDM4EMAPTALDH1A1HSD17B10 | |
| SCHEMBL30522830 | 0.77 | GAA (0.69) | GAAKDM4EMAPTALDH1A1HSD17B10 | |
| SCHEMBL16634589 | 0.76 | MAPK13 (0.78) | GAAKDM4EMAPTALDH1A1HSD17B10 | |
| SCHEMBL2342942 | 0.74 | GAA (1.00) | GAAKDM4EMAPTALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015052675-A1 | SUBSTITUTED DIHYDRO-BENZIMIDAZOLE COMPOUNDS AS ROR GAMMA MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2015-04-16 | — | — | WO | disclosed |