Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFD | P00746 | 14/20 | 0.48 |
| ▸ | TRPA1 | O75762 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16635165 | 1.00 | CFD (0.48) | CFDTRPA1SMN1; SMN2 | |
| SCHEMBL16648088 | 0.85 | FNTA (0.46) | CFDTRPA1 | |
| SCHEMBL16635467 | 0.83 | TRPA1 (0.46) | CFDTRPA1 | |
| SCHEMBL16635520 | 0.79 | TRPA1 (0.47) | CFDTRPA1 | |
| SCHEMBL16635433 | 0.79 | TRPA1 (0.73) | TRPA1 | |
| SCHEMBL18546533 | 0.78 | CFD (0.60) | CFD | |
| SCHEMBL16635248 | 0.78 | TRPA1 (0.47) | CFDTRPA1 | |
| SCHEMBL16635061 | 0.78 | TRPA1 (0.49) | CFDTRPA1 | |
| SCHEMBL17959669 | 0.76 | TRPA1 (0.47) | CFDTRPA1 | |
| SCHEMBL16634887 | 0.76 | TRPA1 (0.47) | CFDTRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3055302-A1 | SUBSTITUTED HETEROCYCLIC SULFONAMIDE COMPOUNDS USEFUL AS TRPA1 MODULATORS | F. Hoffmann-La Roche AG (CH) | 2016-08-17 | — | — | EP | disclosed |
| WO-2015052264-A1 | SUBSTITUTED HETEROCYCLIC SULFONAMIDE COMPOUNDS USEFUL AS TRPA1 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2015-04-16 | — | — | WO | disclosed |