SCHEMBL1663515

SCHEMBL1663515

CC(=O)c1cc2cc(NC(=O)c3ccc(N(C)C)cc3)ccc2n1-c1ccc(Nc2ccc(N(C)C)cc2)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNK3 O14649 2/20 0.46
ECE1 P42892 1/20 0.45
ALDH1A1 P00352 7/20 0.44
MAPT P10636 5/20 0.44
MAPK1 P28482 2/20 0.44
LMNA P02545 3/20 0.42
KDM4E B2RXH2 2/20 0.42
MCL1 Q07820 2/20 0.42
HSD17B10 Q99714 2/20 0.42
TP53 P04637 2/20 0.42
POLB P06746 1/20 0.41
HPGD P15428 1/20 0.41
NAMPT P43490 1/20 0.41
P4HTM Q9NXG6 2/20 0.41
BTK Q06187 1/20 0.41
RAB9A P51151 4/20 0.40
NPC1 O15118 3/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
ROCK2 O75116 2/20 0.40
TSHR P16473 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1663520 0.96 ECE1 (0.49) KCNK3ECE1ALDH1A1MAPTMAPK1
SCHEMBL1664987 0.87 ECE1 (0.43) KCNK3ECE1ALDH1A1MAPTMAPK1
SCHEMBL1664463 0.79 KCNK3 (0.49) KCNK3ALDH1A1MAPTMAPK1LMNA
SCHEMBL1663505 0.77 MAOB (0.54) KCNK3ALDH1A1MAPTMAPK1LMNA
SCHEMBL8769183 0.75 MAPT (0.44) KCNK3ALDH1A1MAPTMAPK1LMNA
SCHEMBL8770238 0.74 MAPT (0.68) KCNK3ALDH1A1MAPTMAPK1LMNA
SCHEMBL1664465 0.74 KCNK3 (0.51) KCNK3ALDH1A1MAPTMAPK1LMNA
SCHEMBL1664498 0.74 MAOB (0.58) KCNK3ALDH1A1MAPTMAPK1LMNA
SCHEMBL1663507 0.73 MAOB (0.56) KCNK3ALDH1A1MAPTMAPK1LMNA
SCHEMBL1666113 0.72 MAOB (0.52) KCNK3ALDH1A1MAPTMAPK1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2642994-A2 USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS Ligand Pharmaceuticals Incorporated (US) 2013-10-02 EP disclosed
EP-2488486-A1 HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES Ligand Pharmaceuticals Inc. (US) 2012-08-22 EP disclosed
WO-2012068406-A2 USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS LIGAND PHARMACEUTICALS INCORPORATED (US) 2012-05-24 WO disclosed
WO-2011046954-A1 HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES LIGAND PHARMACEUTICALS INC. (US) 2011-04-21 WO disclosed