Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 5/20 | 0.38 |
| ▸ | VNN1 | O95497 | 1/20 | 0.38 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30874873 | 0.80 | VNN1 (0.43) | VNN1 | |
| SCHEMBL6168088 | 0.73 | SPHK1 (0.68) | SPHK1SCN3AMAOAMAOB | |
| SCHEMBL6168080 | 0.73 | SPHK1 (0.68) | SPHK1SCN3AMAOAMAOB | |
| SCHEMBL21937412 | 0.73 | CXCR4 (0.37) | — | |
| SCHEMBL5154674 | 0.72 | SPHK1 (0.71) | POLBSPHK1SCN3AMAOAMAOB | |
| SCHEMBL408684 | 0.72 | SPHK1 (0.71) | POLBSPHK1SCN3AMAOAMAOB | |
| SCHEMBL408685 | 0.72 | SPHK1 (0.71) | POLBSPHK1SCN3AMAOAMAOB | |
| SCHEMBL4844700 | 0.71 | SPHK1 (0.59) | POLBSPHK1SCN3AMAOAMAOB | |
| Hydrochloric Acid SCHEMBL28533309 | 0.71 | SPHK1 (0.70) | POLBSPHK1SCN3AMAOAMAOB | |
| Hydrochloric Acid SCHEMBL4368428 | 0.71 | SPHK1 (0.70) | POLBSPHK1SCN3AMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3055302-A1 | SUBSTITUTED HETEROCYCLIC SULFONAMIDE COMPOUNDS USEFUL AS TRPA1 MODULATORS | F. Hoffmann-La Roche AG (CH) | 2016-08-17 | — | — | EP | disclosed |
| WO-2015052264-A1 | SUBSTITUTED HETEROCYCLIC SULFONAMIDE COMPOUNDS USEFUL AS TRPA1 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2015-04-16 | — | — | WO | disclosed |