Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.71 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.61 |
| ▸ | MAOA | P21397 | 3/20 | 0.60 |
| ▸ | MAOB | P27338 | 3/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.52 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.52 |
| ▸ | CCR4 | P51679 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | ACE | P12821 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL408685 | 1.00 | SPHK1 (0.71) | SPHK1SCN3AMAOAMAOBPOLB | |
| SCHEMBL408684 | 1.00 | SPHK1 (0.71) | SPHK1SCN3AMAOAMAOBPOLB | |
| Hydrochloric Acid SCHEMBL4368428 | 0.98 | SPHK1 (0.70) | SPHK1SCN3AMAOAMAOBPOLB | |
| Hydrochloric Acid SCHEMBL28533309 | 0.98 | SPHK1 (0.70) | SPHK1SCN3AMAOAMAOBPOLB | |
| SCHEMBL4723427 | 0.95 | SPHK1 (0.66) | SPHK1SCN3AMAOAMAOBPOLB | |
| SCHEMBL16714052 | 0.90 | SPHK1 (0.60) | SPHK1SCN3AMAOAMAOBPOLB | |
| SCHEMBL3399606 | 0.89 | SPHK1 (0.58) | SPHK1SCN3AMAOAMAOBPOLB | |
| SCHEMBL3055319 | 0.89 | SPHK1 (0.58) | SPHK1SCN3AMAOAMAOBPOLB | |
| SCHEMBL2592830 | 0.89 | SPHK1 (0.58) | SPHK1SCN3AMAOAMAOBPOLB | |
| SCHEMBL2587055 | 0.87 | CYP1A2 (0.60) | SPHK1NPSR1PDCD1CD274CCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1745019-A1 | NOVEL COMPOUNDS OF PROLINE AND MORPHOLINE DERIVATIVES | PFIZER INC. (US) | 2007-01-24 | — | — | EP | disclosed |
| US-20050261290-A1 | Novel compounds of proline and morpholine derivatives | CHENG HENGMIAO | 2005-11-24 | — | — | US | disclosed |
| WO-2005108359-A1 | NOVEL COMPOUNDS OF PROLINE AND MORPHOLINE DERIVATIVES | PFIZER INC. (US) | 2005-11-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050261290-A1 | Novel compounds of proline and morpholine derivatives | CYP11B1, HSD11B1, CYP11B2 | SPHK1 504/4885SCN3A 976/4885MAOA 587/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.