Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 2/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | BMP1 | P13497 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16703049 | 0.86 | ELANE (0.41) | MAPTKDM4ELMNAPOLBNPSR1 | |
| SCHEMBL3227056 | 0.79 | MAPT (0.36) | MAPTKDM4ELMNAPOLBNPSR1 | |
| SCHEMBL2289818 | 0.77 | ELANE (0.42) | MAPTKDM4ELMNAPOLBNPSR1 | |
| SCHEMBL9351782 | 0.76 | MEN1 (0.50) | MAPTKDM4ELMNAPOLBNPSR1 | |
| SCHEMBL9355695 | 0.75 | CYP11B1 (0.36) | MAPTKDM4ELMNAPOLBNPSR1 | |
| SCHEMBL20537070 | 0.74 | KMT2A (0.46) | MAPTLMNANPSR1ALDH1A1ACACB | |
| SCHEMBL2287443 | 0.74 | AKR1C3 (0.37) | MAPTKDM4ELMNAPOLBNPSR1 | |
| SCHEMBL3239407 | 0.73 | ELANE (0.40) | MAPTKDM4ELMNAPOLBNPSR1 | |
| SCHEMBL10527711 | 0.73 | ALDH1A1 (0.46) | MAPTKDM4ELMNAPOLBNPSR1 | |
| SCHEMBL16702787 | 0.73 | MEN1 (0.39) | MAPTKDM4ELMNAPOLBNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3066091-A1 | NMDA ANTAGONIST PRODRUGS | Astrazeneca AB (SE) | 2016-09-14 | — | — | EP | disclosed |
| EP-3054991-A1 | PROTEIN-POLYMER-DRUG CONJUGATES | Mersana Therapeutics, Inc. (US) | 2016-08-17 | — | — | EP | disclosed |
| EP-3054992-A1 | PROTEIN-POLYMER-DRUG CONJUGATES | Asana BioSciences, LLC (US) | 2016-08-17 | — | — | EP | disclosed |
| CN-105683180-A | Nmda antagonist prodrugs | 阿斯利康(瑞典)有限公司 | 2016-06-15 | — | — | CN | disclosed |
| WO-2015067923-A1 | NMDA ANTAGONIST PRODRUGS | ASTRAZENECA AB (SE) | 2015-05-14 | — | — | WO | disclosed |
| WO-2015054659-A1 | PROTEIN-POLYMER-DRUG CONJUGATES | MERSANA THERAPEUTICS, INC. (US) | 2015-04-16 | — | — | WO | disclosed |
| WO-2015054669-A1 | PROTEIN-POLYMER-DRUG CONJUGATES | ASANA BIOSCIENCES, LLC (US) | 2015-04-16 | — | — | WO | disclosed |