Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.32 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.32 |
| ▸ | ADCY10 | Q96PN6 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
| ▸ | USP1 | O94782 | 1/20 | 0.31 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.30 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30280494 | 0.79 | MAP4K4 (0.41) | MAP4K4EGFRTLR7 | |
| SCHEMBL30980419 | 0.74 | ADORA3 (0.48) | MAP4K4PIK3CDADCY10PIK3CB | |
| SCHEMBL5080208 | 0.73 | MAP4K4 (0.47) | MAP4K4EGFRPIK3CDPIK3R1TGFBR1 | |
| SCHEMBL31010615 | 0.73 | MAP4K4 (0.36) | MAP4K4EGFRTLR7 | |
| SCHEMBL807452 | 0.72 | MAP4K4 (0.50) | MAP4K4EGFRPIK3CDPIK3R1ADCY10 | |
| SCHEMBL30997410 | 0.72 | MAP4K4 (0.41) | MAP4K4EGFRTGFBR1PIK3CA | |
| SCHEMBL30989127 | 0.69 | MAP4K4 (0.47) | MAP4K4EGFRPIK3CDPIK3R1ADCY10 | |
| SCHEMBL29350296 | 0.69 | MAP4K4 (0.47) | MAP4K4EGFRPIK3CDPIK3R1ADCY10 | |
| SCHEMBL807453 | 0.69 | MAP4K4 (0.47) | MAP4K4EGFRPIK3CDPIK3R1TGFBR1 | |
| SCHEMBL12314541 | 0.69 | MAP4K4 (0.47) | MAP4K4EGFRPIK3CDPIK3R1ADCY10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3054955-A1 | PYRROLOTRIAZINE KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2016-08-17 | — | — | EP | claimed |
| WO-2015054358-A1 | PYRROLOTRIAZINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-04-16 | — | — | WO | claimed |