Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 2/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | SLC19A2 | O60779 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16635772 | 0.79 | MAP4K4 (0.40) | MAP4K4TLR7EGFR | |
| SCHEMBL5080208 | 0.74 | MAP4K4 (0.47) | MAP4K4TLR7EGFRADORA2AADORA2B | |
| SCHEMBL807452 | 0.73 | MAP4K4 (0.50) | MAP4K4TLR7EGFR | |
| SCHEMBL30980419 | 0.72 | ADORA3 (0.48) | MAP4K4POLBADORA1KDM4ELMNA | |
| SCHEMBL18911313 | 0.71 | PDE10A (0.49) | LCKUSP2KDM4E | |
| SCHEMBL31010615 | 0.71 | MAP4K4 (0.36) | MAP4K4TLR7EGFR | |
| SCHEMBL30989127 | 0.70 | MAP4K4 (0.47) | MAP4K4EGFRADORA2A | |
| SCHEMBL807453 | 0.70 | MAP4K4 (0.47) | MAP4K4EGFRADORA2AADORA2BADORA1 | |
| SCHEMBL12314541 | 0.70 | MAP4K4 (0.47) | MAP4K4EGFRKDM4ELMNA | |
| SCHEMBL29350296 | 0.70 | MAP4K4 (0.47) | MAP4K4EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110300589-B | Bicyclic heteroaryl derivatives as CFTR potentiators | 囊性纤维化基金会 | 2023-03-10 | — | — | CN | disclosed |