Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 12/20 | 0.76 |
| ▸ | MAPT | P10636 | 8/20 | 0.76 |
| ▸ | NPC1 | O15118 | 6/20 | 0.76 |
| ▸ | RAB9A | P51151 | 6/20 | 0.76 |
| ▸ | GAA | P10253 | 2/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.71 |
| ▸ | TP53 | P04637 | 3/20 | 0.71 |
| ▸ | GFER | P55789 | 1/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 3/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1663642 | 0.98 | SMN1; SMN2 (0.72) | SMN1; SMN2MAPTNPC1RAB9AGAA | |
| SCHEMBL1663679 | 0.85 | RAB9A (0.55) | SMN1; SMN2MAPTNPC1RAB9AGAA | |
| SCHEMBL8769706 | 0.84 | RAB9A (0.58) | SMN1; SMN2MAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL1664750 | 0.81 | MAPT (0.49) | SMN1; SMN2MAPTNPC1RAB9AGAA | |
| SCHEMBL8775385 | 0.80 | NPC1 (0.64) | SMN1; SMN2MAPTNPC1RAB9AGAA | |
| SCHEMBL18745976 | 0.79 | KMT2A (0.55) | SMN1; SMN2MAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL21254928 | 0.79 | RAB9A (0.55) | SMN1; SMN2MAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL1664311 | 0.79 | KMT2A (0.55) | SMN1; SMN2MAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL1664752 | 0.79 | MAPT (0.47) | SMN1; SMN2MAPTNPC1RAB9AGAA | |
| SCHEMBL1663536 | 0.78 | RAB9A (0.55) | SMN1; SMN2MAPTNPC1RAB9AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2642994-A2 | USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS | Ligand Pharmaceuticals Incorporated (US) | 2013-10-02 | — | — | EP | disclosed |
| EP-2488486-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | Ligand Pharmaceuticals Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2012068406-A2 | USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2012-05-24 | — | — | WO | disclosed |
| WO-2011046954-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | LIGAND PHARMACEUTICALS INC. (US) | 2011-04-21 | — | — | WO | disclosed |