Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 6/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 5/20 | 0.51 |
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | STAT3 | P40763 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9215131 | 0.81 | ALDH1A1 (0.62) | POLBALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL13461925 | 0.78 | ALDH1A1 (0.62) | POLBALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL10994393 | 0.74 | NPC1 (0.67) | POLBALDH1A1L3MBTL1NPC1RAB9A | |
| SCHEMBL246533 | 0.73 | CYP1A2 (0.51) | POLBALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL10716585 | 0.70 | POLB (0.53) | POLBALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL11108965 | 0.70 | POLB (0.53) | POLBALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL15131088 | 0.69 | POLB (0.48) | POLBALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL23657629 | 0.69 | TP53 (0.78) | POLBNPC1RAB9ASMN1; SMN2LMNA | |
| Hydrochloric Acid SCHEMBL637663 | 0.69 | ALDH1A1 (0.52) | POLBALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL28878659 | 0.67 | ALDH1A1 (0.49) | POLBALDH1A1L3MBTL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3055315-A1 | THIAZOLOPYRIMIDINONES AS MODULATORS OF NMDA RECEPTOR ACTIVITY | F. Hoffmann-La Roche AG (CH) | 2016-08-17 | — | — | EP | disclosed |
| WO-2015052226-A1 | THIAZOLOPYRIMIDINONES AS MODULATORS OF NMDA RECEPTOR ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2015-04-16 | — | — | WO | disclosed |