SCHEMBL16636781

SCHEMBL16636781

CC(C)(C)OC(=O)N1CCN(c2ccnc3cc(Cl)c(-c4ccccc4Cl)cc23)CC1

nearest known ligand 0.51

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
IDE P14735 3/20 0.51
MEN1 O00255 3/20 0.50
KMT2A Q03164 3/20 0.50
CLK1 P49759 1/20 0.47
CNR1 P21554 1/20 0.47
CNR2 P34972 1/20 0.47
SMARCA2 P51531 1/20 0.47
SMARCA4 P51532 1/20 0.47
PBRM1 Q86U86 1/20 0.47
ALDH1A1 P00352 1/20 0.46
KDM4E B2RXH2 2/20 0.45
POLB P06746 1/20 0.45
MAPK1 P28482 3/20 0.44
MAPT P10636 2/20 0.44
CCR5 P51681 1/20 0.44
STAT3 P40763 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
ACHE P22303 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29765687 1.00 IDE (0.51) IDEMEN1KMT2ACLK1CNR1
SCHEMBL17608720 0.94 IDE (0.46) IDEMEN1KMT2ACLK1CNR1
SCHEMBL16637543 0.86 ALDH1A1 (0.51) IDEMEN1KMT2ACLK1ALDH1A1
SCHEMBL16636967 0.85 CNR1 (0.57) CNR1CNR2SMARCA2SMARCA4PBRM1
SCHEMBL13283941 0.85 IDE (0.58) IDEMEN1KMT2ACLK1ALDH1A1
SCHEMBL16647178 0.84 IDE (0.54) IDEMEN1KMT2ACLK1ALDH1A1
SCHEMBL16647038 0.83 CNR1 (0.53) CNR1CNR2SMARCA2SMARCA4PBRM1
SCHEMBL16637622 0.83 ALDH1A1 (0.48) IDEMEN1KMT2ACLK1ALDH1A1
SCHEMBL29765715 0.83 ALDH1A1 (0.48) IDEMEN1KMT2ACLK1ALDH1A1
SCHEMBL3709053 0.80 IDE (0.76) IDEMEN1KMT2ACLK1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12234244-B2 Substituted piperazines as inhibitors of KRAS G12C ARAXES PHARMA LLC (US) 2025-02-25 US disclosed
US-20240352028-A1 SUBSTITUTED QUINAZOLINES AS INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2024-10-24 US disclosed
US-20240043441-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2024-02-08 US disclosed
US-11878985-B2 Substituted quinazolines as inhibitors of KRAS G12C ARAXES PHARMA LLC (US) 2024-01-23 US disclosed
US-20230303586-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2023-09-28 US disclosed
US-20230303586-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2023-09-28 US disclosed
US-20230212183-A9 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2023-07-06 US disclosed
US-20230212183-A9 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2023-07-06 US disclosed
US-20230212183-A9 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2023-07-06 US disclosed
US-20220242875-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2022-08-04 US disclosed
EP-3055290-A1 INHIBITORS OF KRAS G12C Araxes Pharma LLC (US) 2016-08-17 EP disclosed
US-20160166571-A1 COMBINATION THERAPIES FOR TREATMENT OF CANCER ARAXES PHARMA LLC 2016-06-16 US disclosed
US-20160166571-A1 COMBINATION THERAPIES FOR TREATMENT OF CANCER ARAXES PHARMA LLC 2016-06-16 US disclosed
US-20160166571-A1 COMBINATION THERAPIES FOR TREATMENT OF CANCER ARAXES PHARMA LLC 2016-06-16 US disclosed
WO-2016044772-A1 COMBINATION THERAPIES FOR TREATMENT OF CANCER ARAXES PHARMA LLC (US) 2016-03-24 WO disclosed
US-20150239900-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC 2015-08-27 US disclosed
US-20150239900-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC 2015-08-27 US disclosed
US-20150239900-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC 2015-08-27 US disclosed
WO-2015054572-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2015-04-16 WO disclosed
WO-2015054572-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2015-04-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12234244-B2 Substituted piperazines as inhibitors of KRAS G12C KRAS, NRAS, HRAS IDE 1865/4885MEN1 1052/4885KMT2A 382/4885
US-11878985-B2 Substituted quinazolines as inhibitors of KRAS G12C KRAS, NRAS, HRAS IDE 2060/4885MEN1 188/4885KMT2A 736/4885
US-20240352028-A1 SUBSTITUTED QUINAZOLINES AS INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS IDE 2060/4885MEN1 188/4885KMT2A 736/4885
US-20150239900-A1 INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS IDE 834/4885MEN1 138/4885KMT2A 850/4885
US-20230212183-A9 INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS IDE 834/4885MEN1 138/4885KMT2A 850/4885
US-20240043441-A1 INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS IDE 834/4885MEN1 138/4885KMT2A 850/4885
US-20230303586-A1 INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS IDE 834/4885MEN1 138/4885KMT2A 850/4885
US-20220242875-A1 INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS IDE 834/4885MEN1 138/4885KMT2A 850/4885
US-20160166571-A1 COMBINATION THERAPIES FOR TREATMENT OF CANCER KRAS, TP53, HRAS IDE 3969/4885MEN1 872/4885KMT2A 1502/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.