SCHEMBL16637116

SCHEMBL16637116

CCOC(=O)/C(C#N)=C/Nc1ccc(-c2ccc(Cl)cc2)c(Cl)c1

nearest known ligand 0.65

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 2/20 0.58
KDM4E B2RXH2 7/20 0.51
NPSR1 Q6W5P4 3/20 0.51
MAPT P10636 2/20 0.51
RECQL P46063 1/20 0.51
ALDH1A1 P00352 7/20 0.50
RAB9A P51151 2/20 0.47
GAA P10253 3/20 0.47
HPGD P15428 2/20 0.47
SMN1; SMN2 Q16637 2/20 0.47
NPC1 O15118 1/20 0.47
RXFP1 Q9HBX9 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.43
PKM P14618 1/20 0.43
GLA P06280 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
LMNA P02545 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16636931 0.83 ALDH1A1 (0.46) DHODHKDM4EMAPTALDH1A1RAB9A
SCHEMBL16636930 0.83 ALDH1A1 (0.46) DHODHKDM4EMAPTALDH1A1RAB9A
SCHEMBL20824721 0.76 RAB9A (0.58) DHODHKDM4ENPSR1MAPTALDH1A1
SCHEMBL22797073 0.76 RAB9A (0.57) DHODHKDM4ENPSR1MAPTALDH1A1
SCHEMBL11806502 0.75 ALDH1A1 (0.66) DHODHKDM4ENPSR1MAPTALDH1A1
SCHEMBL11806491 0.75 ALDH1A1 (0.66) DHODHKDM4ENPSR1MAPTALDH1A1
SCHEMBL4724694 0.75 ALDH1A1 (0.67) DHODHKDM4ENPSR1MAPTALDH1A1
SCHEMBL14314065 0.75 ALDH1A1 (0.67) DHODHKDM4ENPSR1MAPTALDH1A1
SCHEMBL4724693 0.75 ALDH1A1 (0.67) DHODHKDM4ENPSR1MAPTALDH1A1
SCHEMBL20775209 0.74 NPSR1 (0.61) DHODHKDM4ENPSR1MAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12234244-B2 Substituted piperazines as inhibitors of KRAS G12C ARAXES PHARMA LLC (US) 2025-02-25 US disclosed
US-20240352028-A1 SUBSTITUTED QUINAZOLINES AS INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2024-10-24 US disclosed
US-20240043441-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2024-02-08 US disclosed
US-11878985-B2 Substituted quinazolines as inhibitors of KRAS G12C ARAXES PHARMA LLC (US) 2024-01-23 US disclosed
US-20230303586-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2023-09-28 US disclosed
US-20230303586-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2023-09-28 US disclosed
US-20230212183-A9 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2023-07-06 US disclosed
US-20230212183-A9 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2023-07-06 US disclosed
US-20230212183-A9 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2023-07-06 US disclosed
US-20220242875-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2022-08-04 US disclosed
US-20160166571-A1 COMBINATION THERAPIES FOR TREATMENT OF CANCER ARAXES PHARMA LLC 2016-06-16 US disclosed
US-20160166571-A1 COMBINATION THERAPIES FOR TREATMENT OF CANCER ARAXES PHARMA LLC 2016-06-16 US disclosed
US-20160166571-A1 COMBINATION THERAPIES FOR TREATMENT OF CANCER ARAXES PHARMA LLC 2016-06-16 US disclosed
WO-2016044772-A1 COMBINATION THERAPIES FOR TREATMENT OF CANCER ARAXES PHARMA LLC (US) 2016-03-24 WO disclosed
WO-2016044772-A1 COMBINATION THERAPIES FOR TREATMENT OF CANCER ARAXES PHARMA LLC (US) 2016-03-24 WO disclosed
US-20150239900-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC 2015-08-27 US disclosed
US-20150239900-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC 2015-08-27 US disclosed
US-20150239900-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC 2015-08-27 US disclosed
WO-2015054572-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2015-04-16 WO disclosed
WO-2015054572-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2015-04-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12234244-B2 Substituted piperazines as inhibitors of KRAS G12C KRAS, NRAS, HRAS DHODH 4336/4885KDM4E 2534/4885NPSR1 4345/4885
US-11878985-B2 Substituted quinazolines as inhibitors of KRAS G12C KRAS, NRAS, HRAS DHODH 4096/4885KDM4E 3221/4885NPSR1 4618/4885
US-20240352028-A1 SUBSTITUTED QUINAZOLINES AS INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS DHODH 4096/4885KDM4E 3221/4885NPSR1 4618/4885
US-20150239900-A1 INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS DHODH 4430/4885KDM4E 3220/4885NPSR1 4528/4885
US-20230212183-A9 INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS DHODH 4430/4885KDM4E 3220/4885NPSR1 4528/4885
US-20240043441-A1 INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS DHODH 4430/4885KDM4E 3220/4885NPSR1 4528/4885
US-20230303586-A1 INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS DHODH 4430/4885KDM4E 3220/4885NPSR1 4528/4885
US-20220242875-A1 INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS DHODH 4430/4885KDM4E 3220/4885NPSR1 4528/4885
US-20160166571-A1 COMBINATION THERAPIES FOR TREATMENT OF CANCER KRAS, TP53, HRAS DHODH 1308/4885KDM4E 4202/4885NPSR1 4692/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.