Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 6/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.61 |
| ▸ | APEX1 | P27695 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | GRIA2 | P42262 | 4/20 | 0.48 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.48 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.48 |
| ▸ | PKM | P14618 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16637200 | 0.80 | L3MBTL1 (0.51) | POLBL3MBTL1TDP1APEX1HTT | |
| SCHEMBL636590 | 0.79 | L3MBTL1 (0.56) | POLBL3MBTL1TDP1APEX1HTT | |
| SCHEMBL16636635 | 0.77 | L3MBTL1 (0.53) | POLBL3MBTL1TDP1APEX1HTT | |
| SCHEMBL16636288 | 0.76 | GRIN2A (0.81) | GRIA2GRIN1GRIN2A | |
| SCHEMBL16637603 | 0.75 | GRIN1 (0.57) | POLBL3MBTL1TDP1APEX1HTT | |
| SCHEMBL10996879 | 0.74 | ALDH1A1 (1.00) | POLBL3MBTL1ALDH1A1NPSR1PKM | |
| SCHEMBL17971481 | 0.73 | L3MBTL1 (0.49) | POLBL3MBTL1TDP1APEX1HTT | |
| SCHEMBL11920169 | 0.72 | POLB (0.64) | POLBL3MBTL1TDP1APEX1HTT | |
| SCHEMBL16637415 | 0.72 | GRIN1 (0.60) | POLBL3MBTL1TDP1APEX1HTT | |
| SCHEMBL16636653 | 0.72 | POLB (0.48) | POLBL3MBTL1TDP1APEX1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3055315-A1 | THIAZOLOPYRIMIDINONES AS MODULATORS OF NMDA RECEPTOR ACTIVITY | F. Hoffmann-La Roche AG (CH) | 2016-08-17 | — | — | EP | disclosed |
| WO-2015052226-A1 | THIAZOLOPYRIMIDINONES AS MODULATORS OF NMDA RECEPTOR ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2015-04-16 | — | — | WO | disclosed |