Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | KYAT1 | Q16773 | 3/20 | 0.42 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.42 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.40 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16361973 | 1.00 | MEN1 (0.45) | MEN1KMT2ATHRBKYAT1KCNQ3 | |
| SCHEMBL16324087 | 1.00 | MEN1 (0.45) | MEN1KMT2ATHRBKYAT1KCNQ3 | |
| SCHEMBL19086432 | 0.90 | KCNQ3 (0.48) | MEN1KMT2AKYAT1KCNQ3KCNQ2 | |
| SCHEMBL17572304 | 0.90 | KCNQ3 (0.48) | MEN1KMT2AKYAT1KCNQ3KCNQ2 | |
| SCHEMBL19086431 | 0.90 | KCNQ3 (0.48) | MEN1KMT2AKYAT1KCNQ3KCNQ2 | |
| SCHEMBL21504268 | 0.86 | MEN1 (0.38) | MEN1KMT2AKCNQ3KCNQ2HTT | |
| SCHEMBL19086454 | 0.86 | ALDH1A1 (0.53) | MEN1KMT2AKYAT1HTTKDM4E | |
| SCHEMBL19086453 | 0.86 | ALDH1A1 (0.53) | MEN1KMT2AKYAT1HTTKDM4E | |
| SCHEMBL17572363 | 0.86 | ALDH1A1 (0.53) | MEN1KMT2AKYAT1HTTKDM4E | |
| SCHEMBL10410692 | 0.80 | MAPT (0.59) | MEN1KMT2ATHRBKYAT1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3190111-B1 | PYRAZOLO[3,4-C]PYRIDINE DERIVATIVES | CSPC ZHONGQI PHARMACEUTICAL TECH SHIJIAZHUANG CO LTD (CN) | 2020-05-06 | — | — | EP | disclosed |
| US-9975893-B2 | Pyrazolo[3,4-c]pyridine derivatives | CSPC ZHONGQI PHARMACEUTICAL TECHNOLOGY (SHIJIAZHUANG) CO., LTD. (CN) | 2018-05-22 | — | — | US | disclosed |
| CN-105324382-B | Spirocyclic derivatives, its preparation method and the application of the ketone of 4,5 dihydro-pyrazolos [3,4 c] pyridine 2 | 四川海思科制药有限公司 | 2017-11-10 | — | — | CN | disclosed |
| US-20170291896-A1 | PYRAZOLO[3,4-C]PYRIDINE DERIVATIVES | CSPC ZHONGQI PHARMACEUTICAL TECHNOLOGY (SHIJIAZHUANG) CO., LTD. (CN) | 2017-10-12 | — | — | US | disclosed |
| EP-3190111-A1 | PYRAZOLO[3,4-C]PYRIDINE DERIVATIVES | CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. (CN) | 2017-07-12 | — | — | EP | disclosed |
| CN-105324382-A | 4,5-dihydro-pyrazolo[3,4-c]pyridin-2-one spiro derivative, preparation method and use thereof | SICHUAN HAISCO PHARMACEUTICAL CO LTD | 2016-02-10 | — | — | CN | disclosed |
| WO-2015051713-A1 | 4,5-DIHYDRO-PYRAZOLO[3,4-C]PYRIDIN-2-ONE SPIRO DERIVATIVE, PREPARATION METHOD AND USE THEREOF | 四川海思科制药有限公司 | 2015-04-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170291896-A1 | PYRAZOLO[3,4-C]PYRIDINE DERIVATIVES | F11, TFPI, F2 | MEN1 1111/4885KMT2A 4066/4885THRB 1362/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.