Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.42 |
| ▸ | IL2 | P60568 | 7/20 | 0.41 |
| ▸ | TNF | P01375 | 1/20 | 0.40 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.40 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | CRACR2A | Q9BSW2 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16637004 | 0.95 | IL2 (0.39) | TP53MAPTJAK2JAK1TYK2 | |
| SCHEMBL16636848 | 0.93 | MGAM (0.37) | TP53MAPTIL2MEN1KMT2A | |
| SCHEMBL16636671 | 0.92 | MEN1 (0.37) | TP53MAPTMEN1KMT2ARAB9A | |
| SCHEMBL18038398 | 0.92 | BUB1 (0.39) | TP53MAPTJAK2JAK1TYK2 | |
| SCHEMBL29420780 | 0.92 | BUB1 (0.39) | TP53MAPTJAK2JAK1TYK2 | |
| SCHEMBL16636788 | 0.90 | MEN1 (0.44) | TP53MAPTHTTMEN1KMT2A | |
| SCHEMBL16636744 | 0.89 | IL2 (0.48) | TP53MAPTJAK2JAK1TYK2 | |
| SCHEMBL16636502 | 0.88 | JAK2 (0.40) | TP53MAPTJAK2JAK1TYK2 | |
| SCHEMBL16637041 | 0.88 | IL2 (0.42) | TP53MAPTJAK2JAK1TYK2 | |
| SCHEMBL16636792 | 0.87 | CRACR2A (0.42) | TP53MAPTJAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11752148-B2 | Pyrazine-containing compound | CALCIMEDICA, INC. (US) | 2023-09-12 | — | — | US | disclosed |
| US-20230226058-A1 | METHODS AND COMPOSITIONS FOR TREATING ACUTE KIDNEY INJURY | AVENUE CAPITAL MANAGEMENT II, L.P. | 2023-07-20 | — | — | US | disclosed |
| US-9611263-B2 | Compounds that modulate intracellular calcium | CALCIMEDICA, INC. (US) | 2017-04-04 | — | — | US | disclosed |
| US-9611263-B2 | Compounds that modulate intracellular calcium | CALCIMEDICA, INC. (US) | 2017-04-04 | — | — | US | disclosed |
| US-9611263-B2 | Compounds that modulate intracellular calcium | CALCIMEDICA, INC. (US) | 2017-04-04 | — | — | US | disclosed |
| US-20160229845-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | AVENUE CAPITAL MANAGEMENT II, L.P. | 2016-08-11 | — | — | US | disclosed |
| US-20160229845-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | AVENUE CAPITAL MANAGEMENT II, L.P. | 2016-08-11 | — | — | US | disclosed |
| US-20160229845-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | AVENUE CAPITAL MANAGEMENT II, L.P. | 2016-08-11 | — | — | US | disclosed |
| WO-2015054283-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. (US) | 2015-04-16 | — | — | WO | disclosed |
| WO-2015054283-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. (US) | 2015-04-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11752148-B2 | Pyrazine-containing compound | NFATC1, IAPP, NLRP3 | TP53 1801/4885MAPT 3453/4885JAK2 82/4885 |
| US-20230226058-A1 | METHODS AND COMPOSITIONS FOR TREATING ACUTE KIDNEY INJURY | CAMKK2, CAMKK1, ATF1 | TP53 4166/4885MAPT 4289/4885JAK2 2561/4885 |
| US-20160229845-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | ORAI1, SARAF, RYR2 | TP53 2681/4885MAPT 1478/4885JAK2 2969/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.