Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 12/20 | 0.69 |
| ▸ | PTGS1 | P23219 | 12/20 | 0.69 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.69 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.69 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.69 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.69 |
| ▸ | ALB | P02768 | 1/20 | 0.69 |
| ▸ | ESR1 | P03372 | 1/20 | 0.69 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.69 |
| ▸ | RARB | P10826 | 1/20 | 0.69 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.69 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.69 |
| ▸ | HTR2A | P28223 | 1/20 | 0.69 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.69 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.69 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.69 |
| ▸ | TSHR | P16473 | 1/20 | 0.69 |
| ▸ | BLM | P54132 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24209440 | 0.84 | PTGS2 (0.71) | PTGS2PTGS1AKR1C3LMNACYP2C9 | |
| SCHEMBL16943972 | 0.84 | PTGS2 (0.71) | PTGS2PTGS1AKR1C3LMNACYP2C9 | |
| SCHEMBL31389025 | 0.84 | PTGS2 (0.71) | PTGS2PTGS1AKR1C3LMNACYP2C9 | |
| Ibuprofen SCHEMBL3001 | 0.82 | PTGS1 (1.00) | PTGS2PTGS1AKR1C3LMNACYP2C9 | |
| SCHEMBL7622372 | 0.82 | PTGS2 (0.67) | PTGS2PTGS1AKR1C3LMNACYP2C9 | |
| Ibuprofen SCHEMBL8754799 | 0.82 | PTGS1 (1.00) | PTGS2PTGS1AKR1C3LMNACYP2C9 | |
| Ibuprofen SCHEMBL19439560 | 0.82 | PTGS1 (1.00) | PTGS2PTGS1AKR1C3LMNACYP2C9 | |
| Ibuprofen SCHEMBL239446 | 0.82 | PTGS1 (1.00) | PTGS2PTGS1AKR1C3LMNACYP2C9 | |
| Ibuprofen SCHEMBL19439559 | 0.82 | PTGS1 (1.00) | PTGS2PTGS1AKR1C3LMNACYP2C9 | |
| Dexibuprofen SCHEMBL30091137 | 0.82 | PTGS1 (1.00) | PTGS2PTGS1AKR1C3LMNACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015134467-A1 | METHODS AND COMPOSITIONS FOR DIRECT RADIOACTIVE LABELING OF BIO-ACTIVE MOLECULES AND BUILDING BLOCKS | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2015-09-11 | — | — | WO | disclosed |
| WO-2015054476-A1 | C-HALOGEN BOND FORMATION | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2015-04-16 | — | — | WO | disclosed |