Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ibuprofen. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 5/20 | 1.00 |
| ▸ | PTGS2 known ✓ | P35354 | 5/20 | 1.00 |
| ▸ | CXCR1 | P25024 | 5/20 | 1.00 |
| ▸ | CXCR2 | P25025 | 5/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 2/20 | 1.00 |
| ▸ | AKR1C3 | P42330 | 2/20 | 1.00 |
| ▸ | ALB | P02768 | 1/20 | 1.00 |
| ▸ | ESR1 | P03372 | 1/20 | 1.00 |
| ▸ | ALOX5 | P09917 | 1/20 | 1.00 |
| ▸ | RARB | P10826 | 1/20 | 1.00 |
| ▸ | ADRB3 | P13945 | 1/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 1/20 | 1.00 |
| ▸ | HTR2A | P28223 | 1/20 | 1.00 |
| ▸ | NR1I3 | Q14994 | 1/20 | 1.00 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 1.00 |
| ▸ | CXCL8 | P10145 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | AKR1C2 | P52895 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ibuprofen SCHEMBL1651685 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2CXCR1CXCR2LMNA | |
| Ibuprofen SCHEMBL19439559 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2CXCR1CXCR2LMNA | |
| Ibuprofen SCHEMBL7037276 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2CXCR1CXCR2LMNA | |
| Dexibuprofen SCHEMBL30091137 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2CXCR1CXCR2LMNA | |
| Ibuprofen SCHEMBL239446 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2CXCR1CXCR2LMNA | |
| Dexibuprofen SCHEMBL43531 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2CXCR1CXCR2LMNA | |
| (R)-Ibuprophen SCHEMBL29057 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2CXCR1CXCR2LMNA | |
| Ibuprofen SCHEMBL19439560 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2CXCR1CXCR2LMNA | |
| Ibuprofen SCHEMBL8754799 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2CXCR1CXCR2LMNA | |
| Ibuprofen SCHEMBL5971382 | 0.98 | PTGS1 (0.96) | PTGS1PTGS2CXCR1CXCR2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 257034 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260146925-A1 | SOLID PHASE EXTRACTION OF ACIDIC BIOMARKERS PRESENT IN OIL SAMPLES, SEDIMENTARY ROCK EXTRACTS, AND PLANT MATERIAL | Petróleo Brasileiro S. A. -Petrobras (BR) | 2026-05-28 | — | — | US | claimed |
| EP-4747611-A1 | OPTICAL ELECTRODE ANALYTE DETECTION SYSTEM AND METHODS OF USE | Vital Biosciences Inc. (CA) | 2026-05-27 | — | — | EP | claimed |
| EP-4746852-A1 | LIPID AGGREGATES FOR INTRAARTICULAR ADMINISTRATION | Universität Bern (CH) | 2026-05-27 | — | — | EP | claimed |
| EP-4749288-A1 | COMPOSITIONS FOR DETECTING, CHARACTERIZING, AND REMOVING A BIOFILM | COSA Group GmbH (DE) | 2026-05-27 | — | — | EP | claimed |
| CN-122079799-A | Emodin modified amine curing agent, preparation method thereof, long-acting anti-corrosion coating based on body rust conversion, preparation method and application thereof | — | 2026-05-26 | — | — | CN | claimed |
| CN-122075390-A | Preparation and application of novel cow uterus injectant | — | 2026-05-26 | — | — | CN | claimed |
| CN-117599617-B | Chiral covalent organic framework composite membrane prepared by in-situ growth method and application thereof | CHINA PHARMACEUTICAL UNIVERSITY (CN) | 2026-05-26 | — | — | CN | claimed |
| CN-122070903-A | Liquid slow-release preparation | 上海建毅腾创生物医药科技有限公司 | 2026-05-22 | — | — | CN | claimed |
| CN-122071870-A | Temperature control slow-release functional material for clothes dryer and clothes dryer comprising same | 无锡美芝电器有限公司 | 2026-05-22 | — | — | CN | claimed |
| CN-122070904-A | Non-steroidal anti-inflammatory drug suspension drops and preparation method thereof | 北京阳光诺和药物研究股份有限公司 | 2026-05-22 | — | — | CN | claimed |
| US-4154962-A | Synthesis of hydratropic acid and some of its alkyl derivatives | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 1979-05-15 | — | — | US | claimed |
| US-4152430-A | ANTIINFLAMMATORY AGENTS | WILLIAM H. RORER, INC. (US) | 1979-05-01 | — | — | US | claimed |
| US-4145440-A | WITH SORBITOL, GLYCERIN AND SURFACTANT; GEL RESISTANT, NON-CAKING; ANTIINFLAMMATORY | THE UPJOHN COMPANY (US) | 1979-03-20 | — | — | US | claimed |
| US-4144397-A | Preparation of 2-aryl-propionic acids by direct coupling utilizing a mixed magnesium halide complex | SYNTEX CORPORATION (US) | 1979-03-13 | — | — | US | claimed |
| US-4135051-A | ENOL ETHER OF AN ARYL ALKYL KETONE WITH A THALLIJM SALT, REGENERATION OF THALLIUM SALT BY ADDING PERACID AND REACTIVE METAL COMPOUND | THE UPJOHN COMPANY (US) | 1979-01-16 | — | — | US | claimed |
| US-4021478-A | Preparation of carboxylic acids from glycidonitriles with ionic lewis acids | THE UPJOHN COMPANY (US) | 1977-05-03 | — | — | US | claimed |
| US-4016268-A | CO-ADMINISTERING A BISMUTH SUBSALICYLATE AND AN ANTIINFLAMMATORY AGENT | MORTON-NORWICH PRODUCTS, INC. (US) | 1977-04-05 | — | — | US | claimed |
| US-4008270-A | Process for preparing 2-(substituted phenyl)propionic acids | THE UPJOHN COMPANY (US) | 1977-02-15 | — | — | US | claimed |
| US-3987094-A | PREPARING CARBOXYLIC ACIDS FROM GLYCIDONITRILES | THE UPJOHN COMPANY (US) | 1976-10-19 | — | — | US | claimed |
| US-3975431-A | Preparing carboxylic acids from glycidonitriles through enol acylates | THE UPJOHN COMPANY (US) | 1976-08-17 | — | — | US | claimed |