⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1742463 | 0.86 | — | — | |
| SCHEMBL14118731 | 0.65 | — | — | |
| SCHEMBL3586646 | 0.61 | PER2 (0.37) | — | |
| SCHEMBL16416569 | 0.58 | PIK3CD (0.41) | — | |
| Bicarbonate SCHEMBL30363239 | 0.57 | — | — | |
| SCHEMBL2331425 | 0.55 | PER2 (0.31) | — | |
| SCHEMBL14118650 | 0.54 | — | — | |
| SCHEMBL28429259 | 0.52 | — | — | |
| SCHEMBL3098042 | 0.52 | — | — | |
| SCHEMBL21952207 | 0.51 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4426702-A1 | CONDENSED-PYRAZINE AMINE DERIVATIVES FOR TREATING SCA3 | Skyhawk Therapeutics, Inc. (US) | 2024-09-11 | — | — | EP | disclosed |
| WO-2023081858-A1 | CONDENSED-PYRAZINE AMINE DERIVATIVES FOR TREATING SCA3 | SKYHAWK THERAPEUTICS, INC. (US) | 2023-05-11 | — | — | WO | disclosed |
| EP-3423435-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | Vanderbilt University (US) | 2019-01-09 | — | — | EP | disclosed |
| EP-3055300-A1 | ANTAGONISTS OF PROSTAGLANDIN EP3 RECEPTOR | Pfizer Inc. (US) | 2016-08-17 | — | — | EP | disclosed |
| WO-2015052610-A1 | ANTAGONISTS OF PROSTAGLANDIN EP3 RECEPTOR | PFIZER INC. (US) | 2015-04-16 | — | — | WO | disclosed |