Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PER2 | O15055 | 3/20 | 0.37 |
| ▸ | CRY1 | Q16526 | 3/20 | 0.37 |
| ▸ | CRY2 | Q49AN0 | 3/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CHKA | P35790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2331425 | 0.86 | PER2 (0.31) | PER2 | |
| SCHEMBL22148462 | 0.75 | PER2 (0.35) | PER2CRY1CRY2 | |
| SCHEMBL4637067 | 0.72 | HSD11B1 (0.38) | PER2CRY1CRY2 | |
| SCHEMBL4061960 | 0.65 | — | — | |
| SCHEMBL11936466 | 0.65 | PER2 (0.40) | PER2CRY1CRY2 | |
| SCHEMBL13684368 | 0.61 | PER2 (0.31) | PER2CRY1CRY2 | |
| SCHEMBL11930024 | 0.61 | PER2 (0.33) | PER2CRY1CRY2 | |
| SCHEMBL16637587 | 0.61 | — | — | |
| SCHEMBL15420000 | 0.60 | PTPN1 (0.47) | PER2CRY1CRY2 | |
| SCHEMBL15380715 | 0.60 | OPRL1 (0.34) | PER2CRY1CRY2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7674810-B2 | 1,1-dioxo-1H-1Λ6-benzo[d]isothiazol-3-yl)-4-hydroxy-1,5-dihydro-pyrrol-2-one inhibitors of HCV polymerase | ROCHE PALO ALTO LLC (US) | 2010-03-09 | — | — | US | disclosed |