Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 18/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | HRH2 | P25021 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTR1E | P28566 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | HTR5A | P47898 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL935462 | 0.90 | HTR6 (0.55) | HTR6BCHEADRA2ADRD2ADRA2B | |
| SCHEMBL2812402 | 0.90 | HTR6 (0.55) | HTR6BCHEADRA2ADRD2ADRA2B | |
| SCHEMBL2813836 | 0.90 | HTR6 (0.55) | HTR6BCHEADRA2ADRD2ADRA2B | |
| SCHEMBL6920850 | 0.88 | MCHR1 (0.51) | HTR6BCHEADRA2ADRD2ADRA2B | |
| SCHEMBL2817371 | 0.84 | HTR6 (0.53) | HTR6BCHEADRA2ADRD2ADRA2B | |
| SCHEMBL2814214 | 0.84 | HTR6 (0.53) | HTR6BCHEADRA2ADRD2ADRA2B | |
| SCHEMBL2813218 | 0.77 | HTR6 (0.46) | HTR6ADRA2ADRD2HTR2AHTR2C | |
| SCHEMBL2813093 | 0.77 | HTR6 (0.46) | HTR6ADRA2ADRD2HTR2AHTR2C | |
| SCHEMBL16900352 | 0.77 | HRH1 (0.48) | HTR6BCHEADRA2ADRD2ADRA2B | |
| SCHEMBL16638509 | 0.75 | HRH1 (0.44) | HTR6BCHEADRA2ADRD2ADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9006234-B2 | Bridged heterocyclic compounds and methods of use | MEDIVATION TECHNOLOGIES, INC. (US) | 2015-04-14 | — | — | US | disclosed |