Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 15/20 | 0.48 |
| ▸ | HTR6 | P50406 | 13/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.48 |
| ▸ | HTR2A | P28223 | 3/20 | 0.48 |
| ▸ | HTR2C | P28335 | 3/20 | 0.48 |
| ▸ | HTR7 | P34969 | 3/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | HRH2 | P25021 | 1/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.48 |
| ▸ | HTR1D | P28221 | 1/20 | 0.48 |
| ▸ | HTR1E | P28566 | 1/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
| ▸ | HTR5A | P47898 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12243933 | 0.90 | HRH1 (0.61) | HRH1HTR6ADRA2AHTR2AHTR2C | |
| SCHEMBL12243902 | 0.87 | HRH1 (0.47) | HRH1HTR6ADRA2AHTR2AHTR2C | |
| SCHEMBL12243987 | 0.82 | HRH1 (0.59) | HRH1HTR6ADRA2AHTR2AHTR2C | |
| SCHEMBL12243922 | 0.82 | HRH1 (0.45) | HRH1HTR6ADRA2AHTR2AHTR2C | |
| SCHEMBL12243928 | 0.80 | HTR6 (0.61) | HRH1HTR6ADRA2AHTR2AHTR2C | |
| SCHEMBL15868830 | 0.77 | HRH1 (0.66) | HRH1HTR6ADRA2AHTR2AHTR2C | |
| SCHEMBL16638515 | 0.77 | HTR6 (0.44) | HRH1HTR6ADRA2AHTR2AHTR2C | |
| SCHEMBL18155238 | 0.77 | HRH1 (0.67) | HRH1HTR6ADRA2AHTR2AHTR2C | |
| SCHEMBL15868829 | 0.77 | HTR6 (0.80) | HRH1HTR6ADRA2AHTR2AHTR2C | |
| SCHEMBL1445544 | 0.76 | HDAC2 (0.43) | HRH1HTR6ADRA2AHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9271971-B2 | Pyrido[3,4-B]indoles and methods of use | MEDIVATION TECHNOLOGIES, INC. (US) | 2016-03-01 | — | — | US | disclosed |
| US-9085580-B2 | Pyrido[3,4-B]indoles and methods of use | MEDIVATION TECHNOLOGIES, INC. (US) | 2015-07-21 | — | — | US | disclosed |
| US-9079904-B2 | Pyrido[3,4-B]indoles and methods of use | MEDIVATION TECHNOLOGIES, INC. (US) | 2015-07-14 | — | — | US | disclosed |