Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.68 |
| ▸ | GAA | P10253 | 1/20 | 0.68 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.49 |
| ▸ | AR | P10275 | 5/20 | 0.47 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.43 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7121279 | 0.87 | POLB (0.51) | POLBGAAMAPK14ARALDH1A1 | |
| SCHEMBL29800655 | 0.87 | POLB (0.51) | POLBGAAMAPK14ARALDH1A1 | |
| SCHEMBL12732871 | 0.84 | POLB (0.49) | POLBGAAMAPK14ARALDH1A1 | |
| SCHEMBL3421693 | 0.84 | POLB (0.79) | POLBGAAMAPK14AREZH2 | |
| SCHEMBL30997471 | 0.83 | POLB (0.63) | POLBGAAMAPK14ARCYP3A4 | |
| SCHEMBL20078430 | 0.83 | POLB (0.59) | POLBGAAMAPK14AREZH2 | |
| SCHEMBL8536725 | 0.83 | POLB (0.59) | POLBGAAMAPK14AREZH2 | |
| SCHEMBL29681639 | 0.81 | GAA (0.74) | POLBGAAMAPK14AREZH2 | |
| SCHEMBL22169508 | 0.81 | POLB (1.00) | POLBGAAMAPK14AREZH2 | |
| SCHEMBL9590630 | 0.81 | GAA (0.74) | POLBGAAMAPK14AREZH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9006454-B2 | Dihydroorotate dehydrogenase inhibitors | MERCK SERONO S.A. (CH) | 2015-04-14 | — | — | US | disclosed |