Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | RXRB | P28702 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24921331 | 0.85 | RAB9A (0.40) | APPHRH3POLBRAB9ALMNA | |
| SCHEMBL13144613 | 0.81 | SMN1; SMN2 (0.47) | RAB9ALMNASMN1; SMN2SYKAURKB | |
| SCHEMBL10212057 | 0.79 | ALDH1A1 (0.58) | APPHRH3POLBRAB9ALMNA | |
| SCHEMBL13439784 | 0.78 | APP (0.65) | APPHRH3POLBRAB9ALMNA | |
| SCHEMBL10212095 | 0.77 | HRH3 (0.50) | APPHRH3POLBRAB9ALMNA | |
| SCHEMBL865233 | 0.75 | SYK (0.37) | LMNASMN1; SMN2SYKAURKBINCENP | |
| SCHEMBL23538050 | 0.74 | CYP2D6 (0.38) | LMNAKMT2ASMN1; SMN2MAPTSYK | |
| SCHEMBL24481353 | 0.74 | AR (0.56) | HRH3POLBRAB9ALMNAATM | |
| SCHEMBL29580252 | 0.74 | GRM5 (0.41) | POLBRAB9ALMNAATML3MBTL1 | |
| SCHEMBL10033144 | 0.73 | RAB9A (0.55) | HRH3POLBRAB9ALMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9006454-B2 | Dihydroorotate dehydrogenase inhibitors | MERCK SERONO S.A. (CH) | 2015-04-14 | — | — | US | disclosed |