Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 5/20 | 0.46 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.45 |
| ▸ | HRH1 | P35367 | 4/20 | 0.44 |
| ▸ | HTR6 | P50406 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.38 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12480649 | 0.88 | SIRT2 (0.47) | SIRT2SIRT1HRH1HTR6MEN1 | |
| SCHEMBL16638407 | 0.85 | KMT2A (0.55) | HRH1HTR6MEN1KMT2ALMNA | |
| SCHEMBL13833888 | 0.84 | SIRT2 (0.37) | SIRT2SIRT1HRH1HTR6CYP3A4 | |
| SCHEMBL12480287 | 0.82 | HRH1 (0.57) | HRH1HTR6MEN1KMT2AGRIN2D | |
| SCHEMBL12480635 | 0.81 | HRH1 (0.67) | HRH1HTR6GRIN2DGRIN3BGRIN1 | |
| SCHEMBL16900206 | 0.80 | KMT2A (0.45) | SIRT2HRH1HTR6MEN1KMT2A | |
| SCHEMBL8037324 | 0.80 | HRH1 (0.68) | SIRT2SIRT1HRH1HTR6GRIN1 | |
| SCHEMBL12480779 | 0.79 | HRH1 (0.56) | HRH1HTR6MEN1KMT2AGRIN2D | |
| SCHEMBL12480358 | 0.79 | SIRT2 (0.46) | SIRT2SIRT1HRH1HTR6MEN1 | |
| SCHEMBL8041279 | 0.78 | SIRT2 (0.51) | SIRT2SIRT1HRH1HTR6MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9006263-B2 | Compounds and methods for treatment of hypertension | MEDIVATION TECHNOLOGIES, INC. (US) | 2015-04-14 | — | — | US | disclosed |