Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.32 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.32 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23712823 | 0.98 | KDM4E (0.35) | KDM4EHPGDNPC1RAB9ATSHR | |
| SCHEMBL23712947 | 0.98 | KDM4E (0.35) | KDM4EHPGDNPC1RAB9ATSHR | |
| SCHEMBL10252360 | 0.95 | KDM4E (0.36) | KDM4EHPGDNPC1RAB9ATSHR | |
| SCHEMBL10671834 | 0.72 | AGTR1 (0.40) | KDM4ETSHRALDH1A1LMNAHTT | |
| SCHEMBL1159646 | 0.72 | CYP2C19 (0.41) | HPGDALDH1A1LMNAHTTCYP1A2 | |
| SCHEMBL24575215 | 0.72 | KMT2A (0.33) | KDM4ERAB9ATSHRMAPK10KMT2A | |
| SCHEMBL8277482 | 0.72 | PDCD1 (0.38) | HPGDALDH1A1LMNAHTTCYP1A2 | |
| SCHEMBL17895819 | 0.71 | KDM4E (0.44) | KDM4EHPGDALDH1A1MEN1HTT | |
| SCHEMBL9570441 | 0.69 | KDM4E (0.31) | KDM4EHPGDTSHRALDH1A1HSD17B10 | |
| SCHEMBL9570106 | 0.69 | AGTR1 (0.35) | KDM4EHTTAGTR1AGTR2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9006237-B2 | Fused pyrazine compounds useful for the treatment of degenerative and inflammatory diseases | JANSSEN PHARMACEUTICA NV (BE) | 2015-04-14 | — | — | US | disclosed |