Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4549800 | 0.85 | KDM4E (0.54) | KDM4EGAAHTTTDP1SMN1; SMN2 | |
| SCHEMBL4317497 | 0.73 | HTT (0.49) | KDM4EGAAHTTTDP1SMN1; SMN2 | |
| SCHEMBL1431992 | 0.72 | ALDH1A1 (0.50) | KDM4EGAAHTTSMN1; SMN2LMNA | |
| SCHEMBL27099061 | 0.72 | HTT (0.50) | KDM4EGAAHTTTDP1SMN1; SMN2 | |
| SCHEMBL18673195 | 0.72 | HPGD (0.54) | GAAHTTSMN1; SMN2LMNAKMT2A | |
| SCHEMBL15829741 | 0.71 | GAA (0.50) | KDM4EGAATDP1SMN1; SMN2LMNA | |
| SCHEMBL13580096 | 0.71 | HTT (0.49) | KDM4EGAAHTTTDP1SMN1; SMN2 | |
| SCHEMBL26196694 | 0.71 | ALDH1A1 (0.63) | GAAHTTSMN1; SMN2LMNAKMT2A | |
| SCHEMBL2068949 | 0.71 | GAA (0.49) | KDM4EGAAHTTTDP1LMNA | |
| SCHEMBL26196749 | 0.71 | APLNR (0.51) | KDM4EGAAHTTLMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2540720-B1 | 1,3,4,8-TETRAHYDRO-2H-PYRIDO[1,2-A]PYRAZINE DERIVATIVE AND USE OF SAME AS HIV INTEGRASE INHIBITOR | JAPAN TOBACCO INC (JP) | 2015-04-15 | — | — | EP | disclosed |