Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.57 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.57 |
| ▸ | F10 | P00742 | 1/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.53 |
| ▸ | TOP1 | P11387 | 2/20 | 0.51 |
| ▸ | TERT | O14746 | 1/20 | 0.51 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | MDM4 | O15151 | 2/20 | 0.49 |
| ▸ | TOP2A | P11388 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27621511 | 0.84 | HDAC1 (0.77) | HDAC3HDAC1HDAC2MAPK1NCOR2 | |
| SCHEMBL25223941 | 0.82 | NPC1 (0.56) | MEN1KMT2APDCD1CD274F10 | |
| SCHEMBL10953014 | 0.80 | HDAC3 (0.71) | MEN1KMT2APDCD1CD274F10 | |
| SCHEMBL7409499 | 0.79 | MEN1 (0.61) | MEN1KMT2APDCD1CD274F10 | |
| SCHEMBL28099690 | 0.79 | F10 (0.59) | MEN1KMT2APDCD1CD274F10 | |
| SCHEMBL17744864 | 0.79 | MEN1 (0.66) | MEN1KMT2APDCD1CD274F10 | |
| SCHEMBL15922175 | 0.78 | CA1 (0.57) | MEN1KMT2APDCD1CD274F10 | |
| SCHEMBL1110180 | 0.78 | MDM4 (0.73) | MEN1KMT2AF10HDAC3HDAC1 | |
| Dinaline SCHEMBL21797218 | 0.77 | HDAC1 (0.76) | HDAC3HDAC1HDAC2MAPK1NCOR2 | |
| SCHEMBL3071477 | 0.77 | PLAU (0.72) | MEN1KMT2AHDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488486-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | Ligand Pharmaceuticals Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011046954-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | LIGAND PHARMACEUTICALS INC. (US) | 2011-04-21 | — | — | WO | disclosed |